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Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis — Europe PMC PMID:36862715

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/36862715
DOI: 10.1371/journal.pone.0282223
License (as archived): CC0-1.0
Archived: 2026-10-07T14:07:47.909Z
SHA-256 of the archived text: f32897665f72a84395896e731a72203012cd7f49aa2cdd0b567c431e9744b57e
Stable URL of this page: https://metraipolis.com/documento/dc_bcb68225faa2

How to cite

Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis — Europe PMC PMID:36862715 — Europe PMC (en), https://europepmc.org/article/MED/36862715 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_bcb68225faa2 (Metraipolis archive dc_bcb68225faa2, sha256 f32897665f72a84395896e731a72203012cd7f49aa2cdd0b567c431e9744b57e)

BibTeX

@misc{dcbcb68225faa2,
  title = {Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis — Europe PMC PMID:36862715},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/36862715},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_bcb68225faa2; sha256 f32897665f72a84395896e731a72203012cd7f49aa2cdd0b567c431e9744b57e},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/36862715. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators including acetate-dependent acetyl CoA synthetase 2 (Acss2), Creb binding protein (Cbp), Sirtuin 1 (Sirt1), and Hypoxia Inducible Factor 2α (HIF-2α). We previously shown in mice that exogenous acetate augments growth and metastasis of flank tumors derived from fibrosarcoma-derived HT1080 cells in an Acss2/HIF-2 dependent manner. Colonic epithelial cells are exposed to the highest acetate levels in the body. We reasoned that colon cancer cells, like fibrosarcoma cells, may respond to acetate in a pro-growth manner. In this study, we examine the role of Acss2/HIF-2 signaling in colon cancer. We find that Acss2/HIF-2 signaling is activated by oxygen or glucose deprivation in two human colon cancer-derived cell lines, HCT116 and HT29, and is crucial for colony formation, migration, and invasion in cell culture studies. Flank tumors derived from HCT116 and HT29 cells exhibit augmented growth in mice when supplemented with exogenous acetate in an Acss2/HIF-2 dependent manner. Finally, Acss2 in human colon cancer samples is most frequently localized in the nucleus, consistent with it having a signaling role. Targeted inhibition of Acss2/HIF-2 signaling may have synergistic effects for some colon cancer patients.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2023 (prima pubblicazione 2023-03-02).
Identificativi: PMID 36862715 · PMCID PMC9980813 · DOI 10.1371/journal.pone.0282223.
Descrittori MeSH principali: Fibrosarcoma; Colonic Neoplasms.
Pagina: https://europepmc.org/article/MED/36862715 — https://doi.org/10.1371/journal.pone.0282223. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T14:02:28.733Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.