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NK cells and monocytes modulate primary HTLV-1 infection — Europe PMC PMID:35377924

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/35377924
DOI: 10.1371/journal.ppat.1010416
License (as archived): CC0-1.0
Archived: 2026-10-19T08:29:24.818Z
SHA-256 of the archived text: 67fb3b81cc4a8c26558771bff1a9171b3de1a1de30dc7016d72b5305b52bdd9d
Stable URL of this page: https://metraipolis.com/documento/dc_bc99306d4dcf

How to cite

NK cells and monocytes modulate primary HTLV-1 infection — Europe PMC PMID:35377924 — Europe PMC (en), https://europepmc.org/article/MED/35377924 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_bc99306d4dcf (Metraipolis archive dc_bc99306d4dcf, sha256 67fb3b81cc4a8c26558771bff1a9171b3de1a1de30dc7016d72b5305b52bdd9d)

BibTeX

@misc{dcbc99306d4dcf,
  title = {NK cells and monocytes modulate primary HTLV-1 infection — Europe PMC PMID:35377924},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/35377924},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_bc99306d4dcf; sha256 67fb3b81cc4a8c26558771bff1a9171b3de1a1de30dc7016d72b5305b52bdd9d},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/35377924. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type (HTLV-1WT) or to the HTLV-1p12KO mutant unable to infect replete animals due to a single point mutation in orf-I that inhibits its expression. The orf-I encoded p8/p12 proteins counteract cytotoxic NK and CD8+ T-cells and favor viral DNA persistence in monocytes. Double NK and CD8+ T-cells or CD8 depletion alone accelerated seroconversion in all animals exposed to HTLV-1WT. In contrast, HTLV-1p12KO infectivity was fully restored only when NK cells were also depleted, demonstrating a critical role of NK cells in primary infection. Monocyte/macrophage depletion resulted in accelerated seroconversion in all animals exposed to HTLV-1WT, but antibody titers to the virus were low and not sustained. Seroconversion did not occur in most animals exposed to HTLV-1p12KO. In vitro experiments in human primary monocytes or THP-1 cells comparing HTLV-1WT and HTLV-1p12KO demonstrated that orf-I expression is associated with inhibition of inflammasome activation in primary cells, with increased CD47 "don't-eat-me" signal surface expression in virus infected cells and decreased monocyte engulfment of infected cells. Collectively, our data demonstrate a critical role for innate NK cells in primary infection and suggest a dual role of monocytes in primary infection. On one hand, orf-I expression increases the chances of viral transmission by sparing infected cells from efferocytosis, and on the other may protect the engulfed infected cells by modulating inflammasome activation. These data also suggest that, once infection is established, the stoichiometry of orf-I expression may contribute to the chronic inflammation observed in HTLV-1 infection by modulating monocyte efferocytosis.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2022 (prima pubblicazione 2022-04-04).
Identificativi: PMID 35377924 · PMCID PMC9022856 · DOI 10.1371/journal.ppat.1010416.
Descrittori MeSH principali: Human T-lymphotropic virus 1; HTLV-I Infections.
Pagina: https://europepmc.org/article/MED/35377924 — https://doi.org/10.1371/journal.ppat.1010416. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-19T08:25:31.815Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.