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5-TOET — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/5-TOET
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-06T17:33:13.938Z
SHA-256 of the archived text: 462f4e01394ef345900f7431b763d393fad5323a2b17d18dc0f769f4fecfd79d
Stable URL of this page: https://metraipolis.com/documento/dc_bc4e13d5197e

How to cite

5-TOET — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/5-TOET (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_bc4e13d5197e (Metraipolis archive dc_bc4e13d5197e, sha256 462f4e01394ef345900f7431b763d393fad5323a2b17d18dc0f769f4fecfd79d)

BibTeX

@misc{dcbc4e13d5197e,
  title = {5-TOET — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/5-TOET},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_bc4e13d5197e; sha256 462f4e01394ef345900f7431b763d393fad5323a2b17d18dc0f769f4fecfd79d},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/5-TOET. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

5-TOET, also known as 2-methoxy-4-ethyl-5-methylthioamphetamine or as 5-thio-DOET, is a psychedelic drug of the phenethylamine and amphetamine families related to the DOx psychedelic DOET. It is the analogue of DOET in which the methoxy group at the 5 position has been replaced with a methylthio group. The drug is one of two possible TOET (thio-DOET) positional isomers, the other being 2-TOET. In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 5-TOET's dose as 12 to 25 mg orally and its duration as 8 to 24 hours. Its onset is about 30 minutes and its time to peak is about 4 hours. The drug is around 5-fold less potent than DOET, which has a listed dose range of 2 to 6 mg orally. The effects of 5-TOET have been reported to include closed-eye imagery and fantasy, open-eye visuals such as brightness around objects and visual movement, feelings of joy, beauty, love, and serenity, erotic enhancement, restlessness, lightheadedness, pupil dilation, sleep disturbances, and next-day afterglow as well as lethargy. One user described it as "superb", "exquisite", and potentially "extraordinary". It has much less physical discomfort than 5-TOM. There also appears to be significant interindividual variability in intensity of 5-TOET, with two of eight people being roughly twice as sensitive as the others. In addition, an unintentional overdose in one person, despite a similar dose taken as others, was described as intense, exhausting, and too long-lived. The chemical synthesis of 5-TOET has been described. The phenethylamine analogue, 2C-5-TOET (5-thio-2C-E), has been synthesized, but was not tested and its properties are unknown. 5-TOET was first described in the scientific literature by Alexander Shulgin and Peyton Jacob III in 1983. Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «5-TOET» — https://en.wikipedia.org/wiki/5-TOET
Wikidata Q123582312: «psychoactive chemical compound» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q123582312
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/5-TOET?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1338619912, consultata il 2026-11-06T17:25:39.241Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: d377868dc9c9d0c6777273b97d571a04da92fa798ab1af51789563d124e0d1d8