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14-Methyl-LSD — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/14-Methyl-LSD
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T23:39:11.228Z
SHA-256 of the archived text: 157f57d4e2820003ec0d15bdcfbf4cb4ecc40f3cb0d03bae511dffb59dd35660
Stable URL of this page: https://metraipolis.com/documento/dc_bbdb3a2ff006

How to cite

14-Methyl-LSD — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/14-Methyl-LSD (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_bbdb3a2ff006 (Metraipolis archive dc_bbdb3a2ff006, sha256 157f57d4e2820003ec0d15bdcfbf4cb4ecc40f3cb0d03bae511dffb59dd35660)

BibTeX

@misc{dcbbdb3a2ff006,
  title = {14-Methyl-LSD — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/14-Methyl-LSD},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_bbdb3a2ff006; sha256 157f57d4e2820003ec0d15bdcfbf4cb4ecc40f3cb0d03bae511dffb59dd35660},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/14-Methyl-LSD. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

14-Methyl-LSD, or 14-Me-LSD, is a serotonin 5-HT2A receptor agonist and possible psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is the derivative of LSD with a methyl group at the 14 position. The drug is a highly potent full agonist of the serotonin 5-HT2A receptor, with an EC50Tooltip half-maximal effective concentration of 0.5432 nM and an EmaxTooltip maximal efficacy of 100.5% in an IP-1 assay. Conversely, it is a very weak partial agonist or antagonist of the serotonin 5-HT2B receptor, with an EC50 of 2.319 nM and an Emax of 9.838% in an IP-1 assay. The chemical synthesis of 14-methyl-LSD has been described. The drug's 2-bromo derivative, 2-Br-14-Me-LSD, has also been described. It is a potent serotonin 5-HT2A receptor agonist similarly to 14-methyl-LSD, but with reduced potency and efficacy in comparison. According to the compounds' developers, 14-methyl-LSD may produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, whereas 2-Br-14-Me-LSD may not produce the head-twitch response. 14-Methyl-LSD was described by David E. Nichols and colleagues in association with 2A Biosciences as a key compound in a patent in 2025.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «14-Methyl-LSD» — https://en.wikipedia.org/wiki/14-Methyl-LSD
Wikidata Q139940789 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q139940789
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/14-Methyl-LSD?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1378948331, consultata il 2026-10-07T23:20:08.156Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 009b6b62ee16608f7556cec31dcd22585ff88ad8b2ceae7c78cdd95577eff466