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Evaluating the Effects of Perinatal Exposures to BPSIP on Hepatic Cholesterol Metabolism in Female and Male Offspring ICR Mice — Europe PMC PMID:39298647

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/39298647
DOI: 10.1289/ehp14643
License (as archived): CC0-1.0
Archived: 2026-10-06T15:34:29.988Z
SHA-256 of the archived text: 3c760140c8f033d142df7b5ed9fca279558f1eec61df646428ff910a218a7948
Stable URL of this page: https://metraipolis.com/documento/dc_baeebe9ab2fc

How to cite

Evaluating the Effects of Perinatal Exposures to BPSIP on Hepatic Cholesterol Metabolism in Female and Male Offspring ICR Mice — Europe PMC PMID:39298647 — Europe PMC (en), https://europepmc.org/article/MED/39298647 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_baeebe9ab2fc (Metraipolis archive dc_baeebe9ab2fc, sha256 3c760140c8f033d142df7b5ed9fca279558f1eec61df646428ff910a218a7948)

BibTeX

@misc{dcbaeebe9ab2fc,
  title = {Evaluating the Effects of Perinatal Exposures to BPSIP on Hepatic Cholesterol Metabolism in Female and Male Offspring ICR Mice — Europe PMC PMID:39298647},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/39298647},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_baeebe9ab2fc; sha256 3c760140c8f033d142df7b5ed9fca279558f1eec61df646428ff910a218a7948},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/39298647. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: A broad suite of bisphenol S (BPS) derivatives as alternatives for BPS have been identified in various human biological samples, including 4-hydroxyphenyl 4-isopropoxyphenylsulfone (BPSIP) detected in human umbilical cord plasma and breast milk. However, very little is known about the health outcomes of prenatal BPS derivative exposure to offspring. Objectives: Our study aimed to investigate the response of hepatic cholesterol metabolism by sex in offspring of dams exposed to BPSIP. Methods: Pregnant ICR mice were exposed to 5μg/kg body weight (BW)/day of BPSIP, BPS, or E2 through drinking water from gestational day one until the pups were weaned. The concentration of BPSIP, BPS, or E2 in the plasma and liver of pups was determined by liquid chromatography-tandem mass spectrometry. Metabolic phenotypes were recorded, and histopathology was examined for liver impairment. Transcriptome analysis was employed to characterize the distribution and expression patterns of differentially expressed genes across sexes. The metabolic regulation was validated by quantitative real-time PCR, immunohistochemistry, and immunoblotting. The role of estrogen receptors (ERs) in mediating sex-dependent effects was investigated using animal models and liver organoids. Results: Pups of dams exposed to BPSIP showed a higher serum cholesterol level, and liver cholesterol levels were higher in females and lower in males than in the controls. BPSIP concentration in the male liver was 1.22±0.25 ng/g and 0.69±0.27 ng/g in the female liver. Histopathology analysis showed steatosis and lipid deposition in both male and female offspring. Transcriptome and gene expression analyses identified sex-specific differences in cholesterol biosynthesis, absorption, disposal, and efflux between pups of dams exposed to BPSIP and those in controls. In vivo , chromatin immunoprecipitation analysis revealed that the binding of ERα protein to key genes such as Hmgcr , Pcsk9 , and Abcg5 was attenuated in BPSIP-exposed females compared to controls, while it was enhanced in males. In vitro , the liver organoid experiments demonstrated that restoration of differential expression induced by BPSIP in key genes, such as Hmgcr , Ldlr , and Cyp7a1 , to levels comparable to the controls was only achieved when treated with a combination of ERα agonist and ERβ agonist. Discussion: Findings from this study suggest that perinatal exposure to BPSIP disrupted cholesterol metabolism in a sex-specific manner in a mouse model, in which ERα played a crucial role both in vivo and in vitro . Therefore, it is crucial to systematically evaluate BPS derivatives to protect maternal health during pregnancy and prevent the transmission of metabolic disorders across generations. https://doi.org/10.1289/EHP14643.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2024 (prima pubblicazione 2024-09-19).
Identificativi: PMID 39298647 · PMCID PMC11412574 · DOI 10.1289/ehp14643.
Descrittori MeSH principali: Liver; Mice, Inbred ICR; Phenols; Cholesterol.
Pagina: https://europepmc.org/article/MED/39298647 — https://doi.org/10.1289/ehp14643. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T15:12:56.244Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.