Metraipolis › archive › dc_baba66db25ff

Local-scale phylodynamics reveal differential community impact of SARS-CoV-2 in a metropolitan US county — Europe PMC PMID:38530853

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/38530853
DOI: 10.1371/journal.ppat.1012117
License (as archived): CC0-1.0
Archived: 2026-10-06T20:06:10.537Z
SHA-256 of the archived text: a605a68450e072bd288c262972ce7847213b2d8a5884b12d9a241d57f209eec2
Stable URL of this page: https://metraipolis.com/documento/dc_baba66db25ff

How to cite

Local-scale phylodynamics reveal differential community impact of SARS-CoV-2 in a metropolitan US county — Europe PMC PMID:38530853 — Europe PMC (en), https://europepmc.org/article/MED/38530853 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_baba66db25ff (Metraipolis archive dc_baba66db25ff, sha256 a605a68450e072bd288c262972ce7847213b2d8a5884b12d9a241d57f209eec2)

BibTeX

@misc{dcbaba66db25ff,
  title = {Local-scale phylodynamics reveal differential community impact of SARS-CoV-2 in a metropolitan US county — Europe PMC PMID:38530853},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/38530853},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_baba66db25ff; sha256 a605a68450e072bd288c262972ce7847213b2d8a5884b12d9a241d57f209eec2},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/38530853. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

SARS-CoV-2 transmission is largely driven by heterogeneous dynamics at a local scale, leaving local health departments to design interventions with limited information. We analyzed SARS-CoV-2 genomes sampled between February 2020 and March 2022 jointly with epidemiological and cell phone mobility data to investigate fine scale spatiotemporal SARS-CoV-2 transmission dynamics in King County, Washington, a diverse, metropolitan US county. We applied an approximate structured coalescent approach to model transmission within and between North King County and South King County alongside the rate of outside introductions into the county. Our phylodynamic analyses reveal that following stay-at-home orders, the epidemic trajectories of North and South King County began to diverge. We find that South King County consistently had more reported and estimated cases, COVID-19 hospitalizations, and longer persistence of local viral transmission when compared to North King County, where viral importations from outside drove a larger proportion of new cases. Using mobility and demographic data, we also find that South King County experienced a more modest and less sustained reduction in mobility following stay-at-home orders than North King County, while also bearing more socioeconomic inequities that might contribute to a disproportionate burden of SARS-CoV-2 transmission. Overall, our findings suggest a role for local-scale phylodynamics in understanding the heterogeneous transmission landscape.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2024 (prima pubblicazione 2024-03-26).
Identificativi: PMID 38530853 · PMCID PMC10997136 · DOI 10.1371/journal.ppat.1012117.
Descrittori MeSH principali: Epidemics; COVID-19.
Pagina: https://europepmc.org/article/MED/38530853 — https://doi.org/10.1371/journal.ppat.1012117. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T18:30:56.408Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.