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The TIRS trial: Enrollment procedures and baseline characterization of a pediatric cohort to quantify the epidemiologic impact of targeted indoor residual… — Europe PMC PMID:39292670

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/39292670
DOI: 10.1371/journal.pone.0310480
License (as archived): CC0-1.0
Archived: 2026-10-06T15:34:23.147Z
SHA-256 of the archived text: 4b96e8e6e261318b22fb7dfe5be6ba07edcb69c3395ebdcf1e165e151370820d
Stable URL of this page: https://metraipolis.com/documento/dc_b6dbded91c82

How to cite

The TIRS trial: Enrollment procedures and baseline characterization of a pediatric cohort to quantify the epidemiologic impact of targeted indoor residual… — Europe PMC PMID:39292670 — Europe PMC (en), https://europepmc.org/article/MED/39292670 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_b6dbded91c82 (Metraipolis archive dc_b6dbded91c82, sha256 4b96e8e6e261318b22fb7dfe5be6ba07edcb69c3395ebdcf1e165e151370820d)

BibTeX

@misc{dcb6dbded91c82,
  title = {The TIRS trial: Enrollment procedures and baseline characterization of a pediatric cohort to quantify the epidemiologic impact of targeted indoor residual… — Europe PMC PMID:39292670},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/39292670},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_b6dbded91c82; sha256 4b96e8e6e261318b22fb7dfe5be6ba07edcb69c3395ebdcf1e165e151370820d},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/39292670. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Aedes mosquito-borne viruses (ABVs) place a substantial strain on public health resources in the Americas. Vector control of Aedes mosquitoes is an important public health strategy to decrease or prevent spread of ABVs. The ongoing Targeted Indoor Residual Spraying (TIRS) trial is an NIH-sponsored clinical trial to study the efficacy of a novel, proactive vector control technique to prevent dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV) infections in the endemic city of Merida, Yucatan, Mexico. The primary outcome of the trial is laboratory-confirmed ABV infections in neighborhood clusters. Despite the difficulties caused by the COVID-19 pandemic, by early 2021 the TIRS trial completed enrollment of 4,792 children aged 2-15 years in 50 neighborhood clusters which were allocated to control or intervention arms via a covariate-constrained randomization algorithm. Here, we describe the makeup and ABV seroprevalence of participants and mosquito population characteristics in both arms before TIRS administration. Baseline surveys showed similar distribution of age, sex, and socio-economic factors between the arms. Serum samples from 1,399 children were tested by commercially available ELISAs for presence of anti-ABV antibodies. We found that 45.1% of children were seropositive for one or more flaviviruses and 24.0% were seropositive for CHIKV. Of the flavivirus-positive participants, most were positive for ZIKV-neutralizing antibodies by focus reduction neutralization testing which indicated a higher proportion of participants with previous ZIKV than DENV infections within the cohort. Both study arms had statistically similar seroprevalence for all viruses tested, similar socio-demographic compositions, similar levels of Ae. aegypti infestation, and similar observed mosquito susceptibility to insecticides. These findings describe a population with a high rate of previous exposure to ZIKV and lower titers of neutralizing antibodies against DENV serotypes, suggesting susceptibility to future outbreaks of flaviviruses is possible, but proactive vector control may mitigate these risks.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2024 (prima pubblicazione 2024-09-18).
Identificativi: PMID 39292670 · PMCID PMC11410223 · DOI 10.1371/journal.pone.0310480.
Descrittori MeSH principali: Aedes; Dengue; Insecticides; Mosquito Control; Mosquito Vectors.
Pagina: https://europepmc.org/article/MED/39292670 — https://doi.org/10.1371/journal.pone.0310480. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
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