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Global sociodemographic, clinical, and epidemiological profiling of patients with mycetoma: A systematic review — Europe PMC PMID:40811735

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40811735
DOI: 10.1371/journal.pntd.0013217
License (as archived): CC0-1.0
Archived: 2026-10-07T23:26:30.893Z
SHA-256 of the archived text: 0c3f8cc1fee727dd97bc66698f0334cee29c9f26e8f6f994d171d3be1871c887
Stable URL of this page: https://metraipolis.com/documento/dc_aaeebf419ec8

How to cite

Global sociodemographic, clinical, and epidemiological profiling of patients with mycetoma: A systematic review — Europe PMC PMID:40811735 — Europe PMC (en), https://europepmc.org/article/MED/40811735 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_aaeebf419ec8 (Metraipolis archive dc_aaeebf419ec8, sha256 0c3f8cc1fee727dd97bc66698f0334cee29c9f26e8f6f994d171d3be1871c887)

BibTeX

@misc{dcaaeebf419ec8,
  title = {Global sociodemographic, clinical, and epidemiological profiling of patients with mycetoma: A systematic review — Europe PMC PMID:40811735},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40811735},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_aaeebf419ec8; sha256 0c3f8cc1fee727dd97bc66698f0334cee29c9f26e8f6f994d171d3be1871c887},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40811735. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Mycetoma is a neglected tropical disease that affects subcutaneous tissues. This chronic granulomatous inflammatory disease often leads to high morbidity rates, including amputation, disability and social stigma. Despite its substantial impact, the epidemiology of mycetoma remains largely unknown. This systematic review aimed to establish a global sociodemographic and clinical profile of affected patients and characterise the geographic patterns of the causative organisms of mycetoma. Methods: The study followed the 'Preferred Reporting Items for Systematic Review and Meta-Analysis' (PRISMA). The search strategy covered all key databases without restriction on language, setting, or year of publication. All observational studies in which the mycetoma patients' sociodemographic profile was described were included. Study quality was evaluated using a modified Newcastle-Ottawa Quality Assessment Scale. We calculated the mean percentage of patients reporting sociodemographic and clinical characteristics. We also determined the geographic patterns of the identified causative organism for reported mycetoma patients based on actinomycetoma and eumycetoma aetiology and genus-level taxonomic classifications. The included studies were heterogeneous in terms of population source, data collection method, and reported data from demographic characteristics to outcomes. This, in turn, can be due to the absence of a standardised data reporting form for mycetoma, which has limited the data analysis and our ability to compare patient characteristics and disease epidemiology over time and between regions. Results: Of 16,564 studies identified, 72 met the inclusion criteria, covering 35,004 persons, of which 29,328 were patients with mycetoma. We found that most cases originated from Sudan, India, and Mexico. The disease primarily affected males (74%) and rural residents (73%), with farmers being the most common occupation. Most patients were adults aged between 20 and 50 years (mean 36.2 years), and the lower limb was affected most (77%). Thirty-three percent of patients were cured on treatment, 15% had amputations, and 18% experienced recurrence. Eumycetoma was predominantly identified in Africa and the Arabian Peninsula, and actinomycetoma was more common in India and Mexico. The most common causative species were Madurella mycetomatis and Actinomadura madurae. Conclusion: This review provides a current understanding of the sociodemographic and clinical characteristics of patients with mycetoma worldwide. Most affected cases were adult males and rural residents, with the lower limb involvement being the most common. The distribution of causative organisms varied by region. The variability in outcomes and organisms underscores the complexity of the disease, highlighting the need for further research to understand its global impact.

Tema degli esploratori: diritto e tecnologia (ricerca Europe PMC «Creative Commons license», solo open access).
Pubblicazione: PLoS neglected tropical diseases, 2025 (prima pubblicazione 2025-08-14).
Identificativi: PMID 40811735 · PMCID PMC12617881 · DOI 10.1371/journal.pntd.0013217.
Descrittori MeSH principali: Mycetoma.
Pagina: https://europepmc.org/article/MED/40811735 — https://doi.org/10.1371/journal.pntd.0013217. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T23:07:58.077Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.