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Apert syndrome — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Apert_syndrome
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-09T16:42:18.426Z
SHA-256 of the archived text: 732eb0ea430c04d9133c49ed7035ab7af5b9f925b8967e02901b53ecfa89f8e0
Stable URL of this page: https://metraipolis.com/documento/dc_aaa6ea0372e8

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Apert syndrome — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Apert_syndrome (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_aaa6ea0372e8 (Metraipolis archive dc_aaa6ea0372e8, sha256 732eb0ea430c04d9133c49ed7035ab7af5b9f925b8967e02901b53ecfa89f8e0)

BibTeX

@misc{dcaaa6ea0372e8,
  title = {Apert syndrome — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Apert_syndrome},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_aaa6ea0372e8; sha256 732eb0ea430c04d9133c49ed7035ab7af5b9f925b8967e02901b53ecfa89f8e0},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Apert_syndrome. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Apert syndrome is a form of acrocephalosyndactyly, a congenital disorder characterized by malformations of the skull, face, hands and feet. It is classified as a branchial arch syndrome, affecting the first branchial (or pharyngeal) arch, the precursor of the maxilla and mandible. Disturbances in the development of the branchial arches in fetal development create lasting and widespread effects. In 1906, Eugène Apert, a French physician, described nine people sharing similar attributes and characteristics. Linguistically, in the term "acrocephalosyndactyly", acro is Greek for "peak", referring to the "peaked" head that is common in the syndrome; cephalo, also from Greek, is a combining form meaning "head"; syndactyly refers to webbing of fingers and toes. In embryology, the hands and feet have selective cells that die in a process called selective cell death, or apoptosis, causing separation of the digits. In the case of acrocephalosyndactyly, selective cell death does not occur and skin, and rarely bone, between the fingers and toes fuses. The cranial bones are affected as well, similar to Crouzon syndrome and Pfeiffer syndrome. Craniosynostosis occurs when the fetal skull and facial bones fuse too soon in utero, disrupting normal bone growth. Fusion of different sutures leads to different patterns of growth on the skull. Examples include: trigonocephaly (fusion of the metopic suture), brachycephaly (fusion of the coronal suture and lambdoid suture bilaterally), dolichocephaly (fusion of the sagittal suture), plagiocephaly (fusion of coronal and lambdoidal sutures unilaterally) and oxycephaly or turricephaly (fusion of coronal and lambdoid sutures). Findings for the incidence of the syndrome in the population have varied, with estimates as low as 1 birth in 200,000 provided and 160,000 given as an average by older studies. A study conducted in 1997, however, by the California Birth Defects Monitoring Program found an incidence rate of 1 in 80,645 out of almost 2.5 million live births. Another study conducted in 2002 by the Craniofacial Center, North Texas Hospital for Children, found a higher incidence of about 1 in 65,000 live births.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «Apert syndrome» — https://en.wikipedia.org/wiki/Apert_syndrome
Wikidata Q618246: «malattia» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q618246
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Apert_syndrome?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1317050214, consultata il 2026-11-09T16:38:57.613Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: b186e0501f7bcf7f33af81aa2176bb27ed2dadddb7ec650e7306fc03f1db0122