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Artificial ovary — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Artificial_ovary
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-10T01:30:41.330Z
SHA-256 of the archived text: 584560e1f261e7108ae492d3c79a3f484ca8eecc2b374c51c62fdff7240b50f6
Stable URL of this page: https://metraipolis.com/documento/dc_a6cd06ffcd90

How to cite

Artificial ovary — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Artificial_ovary (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_a6cd06ffcd90 (Metraipolis archive dc_a6cd06ffcd90, sha256 584560e1f261e7108ae492d3c79a3f484ca8eecc2b374c51c62fdff7240b50f6)

BibTeX

@misc{dca6cd06ffcd90,
  title = {Artificial ovary — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Artificial_ovary},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_a6cd06ffcd90; sha256 584560e1f261e7108ae492d3c79a3f484ca8eecc2b374c51c62fdff7240b50f6},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Artificial_ovary. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

An artificial ovary is a potential fertility preservation treatment that aims to mimic the function of the natural ovary. Conventional fertility preservation for females involves oocyte cryopreservation or ovarian tissue cryopreservation. However, there are drawbacks to these treatments. Oocyte cryopreservation is not possible for those with pre-pubertal cancer or premature ovarian insufficiency. Ovarian tissue cryopreservation also poses a risk of reintroducing malignant cells after cancer recovery, particular in those with previous leukaemia. Artificial ovaries could be an effective alternative in fertility preservation. The artificial ovary aims to replicate its natural counterpart by producing oocytes and releasing steroid hormones. To date, no human oocytes have been fertilised or used to produce offspring using an artificial ovary and it is unlikely that this will occur until further research has been completed and bioethical concerns have been considered. Ideally, the artificial ovary should contain follicles or oocytes obtained from ovarian tissue cryopreservation, as well as other ovarian cells to provide growth factors. Isolated follicles are then transplanted (either at the normal site of the ovary or elsewhere in the body) in a delivery scaffold. An ideal biocompatible scaffold would cause minimal inflammation, be suitable for neo-angiogenesis, and degrade after transplantation. There are some limitations to artificial ovaries. From an ethical perspective, there is the issue of justice of who would qualify to receive artificial ovaries (except in autologous transplant) as there is limited availability. There is also a bioethical concerns around pre-implantation diagnosis and genetic manipulation of artificial ovaries. If a patient's own ovarian tissue is used for generating artificial ovaries, the risk of reintroducing malignancy is still present, although this risk would be lowered if only oocytes were used. One area of future research in this field will look at the source of oocytes for artificial ovaries. There is potential for induced pluripotent stem cells (iPSCs) to be used as an alternative source to a patient's own gametes. Although this has not yet been tested with human stem cells, mice transplanted with these cells were able to successfully reproduce through in vitro maturation and fertilisation. However, human iPSCs are known to have mitochondrial DNA mutations even when isolated from healthy donors, therefore there is still more work to be done with this area.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «Artificial ovary» — https://en.wikipedia.org/wiki/Artificial_ovary
Wikidata Q99845191: «fertility preservation treatment» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q99845191
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Artificial_ovary?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1369956236, consultata il 2026-11-10T01:27:45.628Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 334e3b05639358b162dfc95e9479a5c730b0660075e631634b2f89135ba465c1