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Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques — Europe PMC PMID:32956357

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32956357
DOI: 10.1371/journal.pone.0236430
License (as archived): CC0-1.0
Archived: 2026-11-07T10:49:13.777Z
SHA-256 of the archived text: 146233b45f9819b0501984b634317dd3d9005ed6b958daefa52c4753980421c5
Stable URL of this page: https://metraipolis.com/documento/dc_a053eaebfefd

How to cite

Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques — Europe PMC PMID:32956357 — Europe PMC (en), https://europepmc.org/article/MED/32956357 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_a053eaebfefd (Metraipolis archive dc_a053eaebfefd, sha256 146233b45f9819b0501984b634317dd3d9005ed6b958daefa52c4753980421c5)

BibTeX

@misc{dca053eaebfefd,
  title = {Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques — Europe PMC PMID:32956357},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32956357},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_a053eaebfefd; sha256 146233b45f9819b0501984b634317dd3d9005ed6b958daefa52c4753980421c5},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32956357. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Rhesus macaques represent an important species for translational and pre-clinical research studies across a multitude of disease and injury models, including aging. Ketamine anesthesia is used in humans and non-human primates but may be associated with adverse effects, including neuromuscular reactions. The effects of aging on ketamine adverse effects is not well characterized. Urodynamic recordings and electromyography (EMG) studies were performed in aged (>20 years old) and adult (3.9-14.9 years old) female rhesus macaques under an equal and light plane of sedation by constant rate infusion (CRI) of ketamine. A total of 4 of 41 adult subjects (9.7%) showed clinical signs of ketamine-induced abnormal neuromuscular reactivity, whereas a larger portion of 14 of 26 aged subjects showed similar ketamine-induced neuromuscular reactivity (53.8%; P< 0.001). The ketamine CRI rate was 19.8±0.9 mg/kg/h in adults and lower in aged subjects at 16.5±1.4 mg/kg/h (P<0.05). The ketamine CRI rate was negatively correlated with age (r = -0.30, P<0.05, n = 64). The incidence of ketamine reactivity or CRI rate was not different between aged pre-and post-menopausal females. EMG recordings during neuromuscular reactivity showed coordinated activation of multiple muscles, suggesting a central nervous system (CNS) mechanism for ketamine-associated neuromuscular reactivity. The incidence of ketamine-induced neuromuscular reactivity is age related but not affected by the estrous cycle in female rhesus macaques. A coordinated activation of multiple muscles, innervated by different peripheral nerves, suggests that ketamine-induced neuromuscular reactivity originates in the CNS.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2020 (prima pubblicazione 2020-09-21).
Identificativi: PMID 32956357 · PMCID PMC7505584 · DOI 10.1371/journal.pone.0236430.
Descrittori MeSH principali: Aging.
Pagina: https://europepmc.org/article/MED/32956357 — https://doi.org/10.1371/journal.pone.0236430. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-07T10:44:54.089Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.