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Complement membrane attack complex — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Complement_membrane_attack_complex
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T12:31:33.374Z
SHA-256 of the archived text: a191205c204c830b9803c0c87f48882698d3bf13d36080198410798ae1810018
Stable URL of this page: https://metraipolis.com/documento/dc_9f4e670cfcea

How to cite

Complement membrane attack complex — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Complement_membrane_attack_complex (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_9f4e670cfcea (Metraipolis archive dc_9f4e670cfcea, sha256 a191205c204c830b9803c0c87f48882698d3bf13d36080198410798ae1810018)

BibTeX

@misc{dc9f4e670cfcea,
  title = {Complement membrane attack complex — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Complement_membrane_attack_complex},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_9f4e670cfcea; sha256 a191205c204c830b9803c0c87f48882698d3bf13d36080198410798ae1810018},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Complement_membrane_attack_complex. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

The membrane attack complex (MAC) or terminal complement complex (TCC) is a complex of proteins typically formed on the surface of pathogen cell membranes as a result of the activation of the host's complement system, and as such is an effector of the immune system. Antibody-mediated complement activation leads to MAC deposition on the surface of infected cells. Assembly of the MAC leads to pores that disrupt the cell membrane of target cells, leading to cell lysis and death. The MAC is composed of the complement components C5b, C6, C7, C8 and several C9 molecules. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. C5b-6-7-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; categoria «Immunology»).
Fonte: Wikipedia in inglese, voce «Complement membrane attack complex» — https://en.wikipedia.org/wiki/Complement_membrane_attack_complex
Wikidata Q1919945 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q1919945
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Complement_membrane_attack_complex?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1353999734, consultata il 2026-10-07T12:03:58.034Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 41e90e3c36274b632791be3c61dda246bda95ffe9e36477509fc6c76b1cb6d2d