Metraipolis › archive › dc_98a1bdf7c19d

Correlates of immunity — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Correlates_of_immunity
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-06T16:40:47.692Z
SHA-256 of the archived text: e59c6292ea8016b0b21357d41b6959acfd26baeabb2b146c3897bed9af3c7a29
Stable URL of this page: https://metraipolis.com/documento/dc_98a1bdf7c19d

How to cite

Correlates of immunity — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Correlates_of_immunity (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_98a1bdf7c19d (Metraipolis archive dc_98a1bdf7c19d, sha256 e59c6292ea8016b0b21357d41b6959acfd26baeabb2b146c3897bed9af3c7a29)

BibTeX

@misc{dc98a1bdf7c19d,
  title = {Correlates of immunity — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Correlates_of_immunity},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_98a1bdf7c19d; sha256 e59c6292ea8016b0b21357d41b6959acfd26baeabb2b146c3897bed9af3c7a29},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Correlates_of_immunity. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Correlates of immunity or correlates of protection to a virus or other infectious pathogen are measurable signs that a person (or other potential host) is immune, in the sense of being protected against becoming infected and/or developing disease. For many viruses, antibodies and especially neutralizing antibodies serve as a correlate of immunity. Pregnant women, for example, are routinely screened in the UK for rubella antibodies to confirm their immunity, which can cause serious congenital abnormalities in their children. In contrast, for HIV, the simple presence of antibodies is not a correlate of immunity/protection since infected individuals develop antibodies without protection against the disease. The fact that the correlates of immunity/protection remain unclear is a significant barrier to HIV vaccine research. There is evidence that some highly exposed individuals can develop resistance to HIV infection, suggesting that immunity and therefore a vaccine is possible. However, without knowing the correlates of immunity, scientists cannot know exactly what sort of immune response a vaccine would need to stimulate, and the only method of assessing vaccine effectiveness will be through large phase III trials with clinical outcomes (i.e. infection and/or disease, not just laboratory markers). Multiple studies used predictive markers to validate higher levels of neutralizing antibodies corresponding with lower likelihood of breakthrough infection after vaccination in COVID-19.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; categoria «Epidemiology»).
Fonte: Wikipedia in inglese, voce «Correlates of immunity» — https://en.wikipedia.org/wiki/Correlates_of_immunity
Wikidata Q109904789 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q109904789
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Correlates_of_immunity?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1315915022, consultata il 2026-10-06T15:18:35.114Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: c2284f66c7a8258e3c10a39a441fbd15ddc49e565d4e91b793067bf9033c4b08