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DNase I hypersensitive site — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/DNase_I_hypersensitive_site
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T14:51:42.162Z
SHA-256 of the archived text: ccbd395c1a0c86c0359d2c1ab1f0fa8025082250ff51a08623eb2977be2623e0
Stable URL of this page: https://metraipolis.com/documento/dc_9869e55cd63a

How to cite

DNase I hypersensitive site — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/DNase_I_hypersensitive_site (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_9869e55cd63a (Metraipolis archive dc_9869e55cd63a, sha256 ccbd395c1a0c86c0359d2c1ab1f0fa8025082250ff51a08623eb2977be2623e0)

BibTeX

@misc{dc9869e55cd63a,
  title = {DNase I hypersensitive site — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/DNase_I_hypersensitive_site},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_9869e55cd63a; sha256 ccbd395c1a0c86c0359d2c1ab1f0fa8025082250ff51a08623eb2977be2623e0},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/DNase_I_hypersensitive_site. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

In genetics, DNase I hypersensitive sites (DHSs) are regions of chromatin that are sensitive to cleavage by the DNase I enzyme. In these specific regions of the genome, chromatin has lost its condensed structure, exposing the DNA and making it accessible. This raises the availability of DNA to degradation by enzymes, such as DNase I. These accessible chromatin zones are functionally related to transcriptional activity, since this remodeled state is necessary for the binding of proteins such as transcription factors. Since the discovery of DHSs 30 years ago, they have been used as markers of regulatory DNA regions. These regions have been shown to map many types of cis-regulatory elements including promoters, enhancers, insulators, silencers and locus control regions. A high-throughput measure of these regions is available through DNase-Seq.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; categoria «Molecular biology»).
Fonte: Wikipedia in inglese, voce «DNase I hypersensitive site» — https://en.wikipedia.org/wiki/DNase_I_hypersensitive_site
Wikidata Q17119065 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q17119065
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/DNase_I_hypersensitive_site?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1339510733, consultata il 2026-10-07T14:24:36.637Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: d65cad09f6663c3321a2da03d333efcdb76a0ab04c56b97cbe7c04fe550db232