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Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea — Europe PMC PMID:37539863

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/37539863
DOI: 10.7554/elife.86233
License (as archived): CC0-1.0
Archived: 2026-10-07T12:29:23.536Z
SHA-256 of the archived text: 00d7cbe99a86ad031f77c07049dc81963afc6849bb74d819760ed29c68483f7f
Stable URL of this page: https://metraipolis.com/documento/dc_97ba19c19d28

How to cite

Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea — Europe PMC PMID:37539863 — Europe PMC (en), https://europepmc.org/article/MED/37539863 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_97ba19c19d28 (Metraipolis archive dc_97ba19c19d28, sha256 00d7cbe99a86ad031f77c07049dc81963afc6849bb74d819760ed29c68483f7f)

BibTeX

@misc{dc97ba19c19d28,
  title = {Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea — Europe PMC PMID:37539863},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/37539863},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_97ba19c19d28; sha256 00d7cbe99a86ad031f77c07049dc81963afc6849bb74d819760ed29c68483f7f},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/37539863. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

In vertebrates with elongated auditory organs, mechanosensory hair cells (HCs) are organised such that complex sounds are broken down into their component frequencies along a proximal-to-distal long (tonotopic) axis. Acquisition of unique morphologies at the appropriate position along the chick cochlea, the basilar papilla, requires that nascent HCs determine their tonotopic positions during development. The complex signalling within the auditory organ between a developing HC and its local niche along the cochlea is poorly understood. Using a combination of live imaging and NAD(P)H fluorescence lifetime imaging microscopy, we reveal that there is a gradient in the cellular balance between glycolysis and the pentose phosphate pathway in developing HCs along the tonotopic axis. Perturbing this balance by inhibiting different branches of cytosolic glucose catabolism disrupts developmental morphogen signalling and abolishes the normal tonotopic gradient in HC morphology. These findings highlight a causal link between graded morphogen signalling and metabolic reprogramming in specifying the tonotopic identity of developing HCs.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2023 (prima pubblicazione 2023-08-04).
Identificativi: PMID 37539863 · PMCID PMC10425173 · DOI 10.7554/elife.86233.
Parole chiave degli autori: Development; Metabolism; Cell biology; Hair cells; Chicken; developmental biology; inner ear; Morphogen.
Descrittori MeSH principali: Cochlea; Chickens.
Pagina: https://europepmc.org/article/MED/37539863 — https://doi.org/10.7554/elife.86233. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T12:01:43.317Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.