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Synthetic genetic array — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Synthetic_genetic_array
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T23:10:17.351Z
SHA-256 of the archived text: 71ac4765bd2b530a52998b291d07b1b94dd95de0e9c6046246540b5a031a7f60
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How to cite

Synthetic genetic array — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Synthetic_genetic_array (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_951cc460ced2 (Metraipolis archive dc_951cc460ced2, sha256 71ac4765bd2b530a52998b291d07b1b94dd95de0e9c6046246540b5a031a7f60)

BibTeX

@misc{dc951cc460ced2,
  title = {Synthetic genetic array — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Synthetic_genetic_array},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_951cc460ced2; sha256 71ac4765bd2b530a52998b291d07b1b94dd95de0e9c6046246540b5a031a7f60},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Synthetic_genetic_array. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Synthetic genetic array analysis (SGA) is a high-throughput technique for exploring synthetic lethal and synthetic sick genetic interactions (SSL). SGA allows for the systematic construction of double mutants using a combination of recombinant genetic techniques, mating and selection steps. Using SGA methodology a query gene deletion mutant can be crossed to an entire genome deletion set to identify any SSL interactions, yielding functional information of the query gene and the genes it interacts with. A large-scale application of SGA in which ~130 query genes were crossed to the set of ~5000 viable deletion mutants in yeast revealed a genetic network containing ~1000 genes and ~4000 SSL interactions. The results of this study showed that genes with similar function tend to interact with one another and genes with similar patterns of genetic interactions often encode products that tend to work in the same pathway or complex. Synthetic Genetic Array analysis was initially developed using the model organism S. cerevisiae. This method has since been extended to cover 30% of the S. cerevisiae genome. Methodology has since been developed to allow SGA analysis in S.pombe and E. coli.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; categoria «Genetics»).
Fonte: Wikipedia in inglese, voce «Synthetic genetic array» — https://en.wikipedia.org/wiki/Synthetic_genetic_array
Wikidata Q7662758 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q7662758
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Synthetic_genetic_array?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1335105430, consultata il 2026-10-07T22:48:38.276Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 2da3e8a48a15956aeb82a3c0eb06a2579ddeee5542d2aaa2413f25557ee180d2