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Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents — Europe PMC PMID:32074458

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32074458
DOI: 10.1289/ehp4709
License (as archived): CC0-1.0
Archived: 2026-11-09T12:11:56.524Z
SHA-256 of the archived text: a7d97bbf318ff058cc28e729346f1f367b3db0012b13ad5b8944a2a198e51125
Stable URL of this page: https://metraipolis.com/documento/dc_8b45fff5600a

How to cite

Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents — Europe PMC PMID:32074458 — Europe PMC (en), https://europepmc.org/article/MED/32074458 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_8b45fff5600a (Metraipolis archive dc_8b45fff5600a, sha256 a7d97bbf318ff058cc28e729346f1f367b3db0012b13ad5b8944a2a198e51125)

BibTeX

@misc{dc8b45fff5600a,
  title = {Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents — Europe PMC PMID:32074458},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32074458},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_8b45fff5600a; sha256 a7d97bbf318ff058cc28e729346f1f367b3db0012b13ad5b8944a2a198e51125},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32074458. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Air pollution has been related to brain structural alterations, but a relationship with white matter microstructure is unclear. Objectives: We assessed whether pregnancy and childhood exposures to air pollution are related to white matter microstructure in preadolescents. Methods: We used data of 2,954 children from the Generation R Study, a population-based birth cohort from Rotterdam, Netherlands (2002-2006). Concentrations of 17 air pollutants including nitrogen oxides (NOX), particulate matter (PM), and components of PM were estimated at participants' homes during pregnancy and childhood using land-use regression models. Diffusion tensor images were obtained at child's 9-12 years of age, and fractional anisotropy (FA) and mean diffusivity (MD) were computed. We performed linear regressions adjusting for socioeconomic and lifestyle characteristics. Single-pollutant analyses were followed by multipollutant analyses using the Deletion/Substitution/Addition (DSA) algorithm. Results: In the single-pollutant analyses, higher concentrations of several air pollutants during pregnancy or childhood were associated with significantly lower FA or higher MD (p<0.05). In multipollutant models of pregnancy exposures selected by DSA, higher concentration of fine particles was associated with significantly lower FA [-0.71 (95% CI: -1.26, -0.16) per 5 μg/m3 fine particles] and higher concentration of elemental silicon with significantly higher MD [0.06 (95% CI: 0.01, 0.11) per 100 ng/m3 silicon]. Multipollutant models of childhood exposures selected by DSA indicated significant associations of NOX with FA [-0.14 (95% CI: -0.23, -0.04) per 20-μg/m3 NOX increase], and of elemental zinc and the oxidative potential of PM with MD [0.03 (95% CI: 0.01, 0.04) per 10-ng/m3 zinc increase and 0.07 (95% CI: 0.00, 0.44) per 1-nmol DTT/min/m3 oxidative potential increase]. Mutually adjusted models of significant exposures during pregnancy and childhood indicated significant associations of silicon during pregnancy, and zinc during childhood, with MD. Discussion: Exposure in pregnancy and childhood to air pollutants from tailpipe and non-tailpipe emissions were associated with lower FA and higher MD in white matter of preadolescents. https://doi.org/10.1289/EHP4709.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2020 (prima pubblicazione 2020-02-13).
Identificativi: PMID 32074458 · PMCID PMC7064320 · DOI 10.1289/ehp4709.
Pagina: https://europepmc.org/article/MED/32074458 — https://doi.org/10.1289/ehp4709. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-09T12:07:22.779Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.