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Occupational Exposure to Disinfectants and Risk of Incident Cardiovascular Disease among US Nurses: The Nurses' Health Study II — Europe PMC PMID:40163383

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40163383
DOI: 10.1289/ehp14945
License (as archived): CC0-1.0
Archived: 2026-10-06T10:17:47.099Z
SHA-256 of the archived text: 24cb0f08cfef25039caf31f4d3d5c4171783ac915af81a13de90fc56b720d8f4
Stable URL of this page: https://metraipolis.com/documento/dc_8a228ea32600

How to cite

Occupational Exposure to Disinfectants and Risk of Incident Cardiovascular Disease among US Nurses: The Nurses' Health Study II — Europe PMC PMID:40163383 — Europe PMC (en), https://europepmc.org/article/MED/40163383 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_8a228ea32600 (Metraipolis archive dc_8a228ea32600, sha256 24cb0f08cfef25039caf31f4d3d5c4171783ac915af81a13de90fc56b720d8f4)

BibTeX

@misc{dc8a228ea32600,
  title = {Occupational Exposure to Disinfectants and Risk of Incident Cardiovascular Disease among US Nurses: The Nurses' Health Study II — Europe PMC PMID:40163383},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40163383},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_8a228ea32600; sha256 24cb0f08cfef25039caf31f4d3d5c4171783ac915af81a13de90fc56b720d8f4},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40163383. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Exposure to certain chemicals in disinfectants has been associated with vascular dysfunction in toxicological studies, but the association between disinfectant exposure and clinical cardiovascular disease (CVD) remains unclear. Objective: The aim of this study was to evaluate the association between occupational exposure to disinfectants and subsequent risk of CVD among US nurses. Methods: We included 75,675 participants from The Nurses' Health Study II who maintained a nursing job and reported data on occupational disinfectant exposure. We estimated hazard ratios (HR) and 95% confidence intervals (CIs) of incident CVD, including coronary heart disease (CHD) and stroke, using Cox proportional hazard models comparing job types and general disinfection tasks between participants. We also used a job-task-exposure matrix to evaluate the risk of CVD by frequency of cleaning/disinfection tasks and exposure levels of seven specific disinfectants (formaldehyde, glutaraldehyde, hypochlorite bleach, hydrogen peroxide, alcohol, quaternary ammonium compounds, and enzymatic cleaners). Results: During 10 y of follow-up (2009-2019), we documented 726 incident cases of CVD. In fully adjusted models, the hazard ratio of CVD among nurses who worked in operating rooms was 1.72 [95% confidence interval (CI): 1.25, 2.36], in comparison with those working as educators or administrators. A similar pattern of associations was found when we separately assessed the risk for CHD and stroke [HR=1.69 (95% CI: 1.11, 2.58) and HR=1.69 (95% CI: 1.05, 2.74), respectively] among operating room nurses, in comparison with those working as educators or administrators. Those who used disinfectants weekly had modest elevations in CVD risk (HR=1.21; 95% CI: 1.04, 1.40), in comparison with women who never used disinfectants. The highest CVD risk was observed among nurses using disinfectants or spray or aerosol products 4-7 d/wk and those exposed to the highest levels of the seven specific disinfectants listed above. Conclusion: Exposure to disinfectants in real-world health care settings was associated with a higher risk of CVD, including CHD and stroke, among US nurses. https://doi.org/10.1289/EHP14945.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2025 (prima pubblicazione 2025-05-09).
Identificativi: PMID 40163383 · PMCID PMC12063792 · DOI 10.1289/ehp14945.
Descrittori MeSH principali: Cardiovascular Diseases; Disinfectants; Occupational Exposure; Nurses.
Pagina: https://europepmc.org/article/MED/40163383 — https://doi.org/10.1289/ehp14945. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T09:45:27.682Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.