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Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus… — Europe PMC PMID:31490965

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31490965
DOI: 10.1371/journal.pone.0221159
License (as archived): CC0-1.0
Archived: 2026-11-10T16:19:20.594Z
SHA-256 of the archived text: 93562c7334e70060e739fc6e5f3a12ff96d11140595f20a64ac542c639e42bcd
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How to cite

Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus… — Europe PMC PMID:31490965 — Europe PMC (en), https://europepmc.org/article/MED/31490965 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_87bca010afba (Metraipolis archive dc_87bca010afba, sha256 93562c7334e70060e739fc6e5f3a12ff96d11140595f20a64ac542c639e42bcd)

BibTeX

@misc{dc87bca010afba,
  title = {Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus… — Europe PMC PMID:31490965},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31490965},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_87bca010afba; sha256 93562c7334e70060e739fc6e5f3a12ff96d11140595f20a64ac542c639e42bcd},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31490965. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Gender differences in Human immunodeficiency virus (HIV) disease progression and comorbidities have been extensively reported. Using the simian immunodeficiency virus (SIV) infected rhesus macaque model, we show that these differences are apparent very early during the course of infection. Though there were no major changes in the proportions of CD4 T cells or its subsets, central memory CD4 T cells from female macaques were found to differentially regulate a significantly larger number of genes at day 4 post-infection (PI) as compared to males. Pathway analysis revealed divergence of both canonical and biological pathways that persisted at day 10 PI. Changes in gene expression profiles were accompanied by a significant increase in plasma levels of pro-inflammatory mediators such as MCP-1/CCL2, I-TAC/CXCL11, and MIF. Though plasma levels of IFNα did not differ between male and female macaques, the expression levels of IFNα subtype-14, 16, IFNβ, and IFNω were significantly upregulated in the lymph nodes of female macaques at day 10 PI as compared to male macaques. Our results suggest that the pathogenic sequelae seen during chronic infection may be shaped by gender differences in immune responses induced very early during the course of HIV infection.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2019 (prima pubblicazione 2019-09-06).
Identificativi: PMID 31490965 · PMCID PMC6730907 · DOI 10.1371/journal.pone.0221159.
Descrittori MeSH principali: Gene Expression Profiling; Sex Characteristics; Immunity, Innate.
Pagina: https://europepmc.org/article/MED/31490965 — https://doi.org/10.1371/journal.pone.0221159. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-10T16:16:41.114Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.