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Disruptions in gene interaction networks abolish host susceptibility to Trichostrongylus colubriformis infections in sheep — Europe PMC PMID:40811742

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40811742
DOI: 10.1371/journal.pntd.0013399
License (as archived): CC0-1.0
Archived: 2026-10-08T03:29:02.031Z
SHA-256 of the archived text: cf490e637eedce34db12e1a0b95c1119c5dc3b458898015b9d10ee61a5d6fb3a
Stable URL of this page: https://metraipolis.com/documento/dc_85fcc9dfe7bb

How to cite

Disruptions in gene interaction networks abolish host susceptibility to Trichostrongylus colubriformis infections in sheep — Europe PMC PMID:40811742 — Europe PMC (en), https://europepmc.org/article/MED/40811742 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_85fcc9dfe7bb (Metraipolis archive dc_85fcc9dfe7bb, sha256 cf490e637eedce34db12e1a0b95c1119c5dc3b458898015b9d10ee61a5d6fb3a)

BibTeX

@misc{dc85fcc9dfe7bb,
  title = {Disruptions in gene interaction networks abolish host susceptibility to Trichostrongylus colubriformis infections in sheep — Europe PMC PMID:40811742},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40811742},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_85fcc9dfe7bb; sha256 cf490e637eedce34db12e1a0b95c1119c5dc3b458898015b9d10ee61a5d6fb3a},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40811742. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

The roundworm Trichostrongylus colubriformis is one of the most important parasites in sheep, impairing feed conversion and reducing growth. However, the molecular mechanism of host resistance to this important species remains elusive. In this study, we compared gene interaction networks manifested in the jejunum transcriptome between sheep bred for parasite resistance (RES) and susceptibility (SUS) in response to a T. colubriformis challenge infection. Selections for host resistance compromised parasite establishment and resulted in a 98.8% reduction in worm burden (P < 0.00001; N = 20 per group). 319 genes displayed a significant difference in transcript abundance between RES and SUS phenotypes. The gene encoding lectin, galactoside-binding, soluble, 15 (LGALS15) had significantly higher expression in RES than SUS lambs. Enriched pathways included antigen processing and presentation and Fc gamma R-mediated phagocytosis. Two algorithms, weighted gene co-expression network analysis (WGCNA) and differential gene correlation analysis (DGCA), were applied to infer gene interaction networks. Both algorithms demonstrate that genes in SUS lambs appear to be more closely correlated than in RES lambs. WGCNA identified a module that was positively correlated with worm counts only in SUS animals (R = 0.67; P = 0.001). DGCA detected approximately four times more unique gene correlation pairs in SUS than in RES lambs. Gene Ontology analysis among the genes with gain-of-correlations shows marked differences in cell division, such as mitotic cytokinesis, sister chromatid segregation, and kinetochore, between the two phenotypes. Correlated genes unique to RES can be used for the development of alternative biomarkers to facilitate breeding. Moreover, dietary approaches to disrupt close gene interactions within key modules may have the potential to reduce worm burden. It is conceivable that feeds, phytochemicals or feed additives that promote specific gene interactions can be used for sustainable parasite controls.

Tema degli esploratori: ricerca e scienza aperta (ricerca Europe PMC «preprint», solo open access).
Pubblicazione: PLoS neglected tropical diseases, 2025 (prima pubblicazione 2025-08-14).
Identificativi: PMID 40811742 · PMCID PMC12370191 · DOI 10.1371/journal.pntd.0013399.
Descrittori MeSH principali: Trichostrongylus; Trichostrongylosis; Sheep Diseases; Genetic Predisposition to Disease; Gene Regulatory Networks.
Pagina: https://europepmc.org/article/MED/40811742 — https://doi.org/10.1371/journal.pntd.0013399. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-08T03:08:05.512Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.