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Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence — Europe PMC PMID:31600226

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31600226
DOI: 10.1371/journal.pone.0220270
License (as archived): CC0-1.0
Archived: 2026-11-10T08:28:30.331Z
SHA-256 of the archived text: ba0aef02aa46f3ea7703b06d97b3aad5f2b221495e0808ec58c8645706afe3b8
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How to cite

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence — Europe PMC PMID:31600226 — Europe PMC (en), https://europepmc.org/article/MED/31600226 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_84e2bc0dcbca (Metraipolis archive dc_84e2bc0dcbca, sha256 ba0aef02aa46f3ea7703b06d97b3aad5f2b221495e0808ec58c8645706afe3b8)

BibTeX

@misc{dc84e2bc0dcbca,
  title = {Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence — Europe PMC PMID:31600226},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31600226},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_84e2bc0dcbca; sha256 ba0aef02aa46f3ea7703b06d97b3aad5f2b221495e0808ec58c8645706afe3b8},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31600226. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Methamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement of TAAR1 in MA dependence. Methods: Participants (n = 106) with active MA dependence (MA-ACT), in remission from MA dependence (MA-REM), with active polysubstance dependence, in remission from polysubstance dependence, and with no history of substance dependence completed neuropsychiatric symptom questionnaires and provided blood samples. In vitro expression and function of CV and wild type TAAR1 receptors were also measured. Results: The V288V polymorphism demonstrated a 40% increase in TAAR1 protein expression in cell culture, but message sequence and protein function were unchanged, suggesting an increase in translation efficiency. Principal components analysis resolved neuropsychiatric symptoms into four components, PC1 (depression, anxiety, memory, and fatigue), PC2 (pain), PC3 (drug and alcohol craving), and PC4 (sleep disturbances). Analyses of study group and TAAR1 genotype revealed a significant interaction for PC3 (craving response) (p = 0.003). The control group showed no difference in PC3 associated with TAAR1, while adjusted mean craving for the MA-ACT and MA-REM groups, among those with at least one copy of V288V, was estimated to be, respectively, 1.55 (p = 0.036) and 1.77 (p = 0.071) times the adjusted mean craving for those without the TAAR1 SNP. Conclusions: Neuroadaptation to chronic MA use may be altered by TAAR1 genotype and result in increased dopamine signaling and craving in individuals with the V288V genotype.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2019 (prima pubblicazione 2019-10-10).
Identificativi: PMID 31600226 · PMCID PMC6786581 · DOI 10.1371/journal.pone.0220270.
Descrittori MeSH principali: Polymorphism, Single Nucleotide.
Pagina: https://europepmc.org/article/MED/31600226 — https://doi.org/10.1371/journal.pone.0220270. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-10T08:24:28.076Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.