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5-HT-moduline — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/5-HT-moduline
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-06T17:31:52.882Z
SHA-256 of the archived text: f5b339112e54cdb850c6c9bea9a0d7b9b2ec9cdd224b9e7eab855b79e2d37c5f
Stable URL of this page: https://metraipolis.com/documento/dc_7ffc3fb2146a

How to cite

5-HT-moduline — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/5-HT-moduline (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_7ffc3fb2146a (Metraipolis archive dc_7ffc3fb2146a, sha256 f5b339112e54cdb850c6c9bea9a0d7b9b2ec9cdd224b9e7eab855b79e2d37c5f)

BibTeX

@misc{dc7ffc3fb2146a,
  title = {5-HT-moduline — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/5-HT-moduline},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_7ffc3fb2146a; sha256 f5b339112e54cdb850c6c9bea9a0d7b9b2ec9cdd224b9e7eab855b79e2d37c5f},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/5-HT-moduline. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

5-Hydroxytryptamine-moduline, also known as 5-HT-moduline or serotonin-moduline as well as Leu-Ser-Ala-Leu (LSAL), is an endogenous neuropeptide and high-affinity serotonin 5-HT1B and 5-HT1D receptor negative allosteric modulator. It is produced in the brain and is co-localized with serotonin 5-HT1B receptor-expressing neurons. The compound has been shown to induce desensitization of serotonin 5-HT1B receptors. It has been found to increase dopamine release in the striatum in rodents. By inhibiting serotonin 5-HT1B autoreceptors, 5-HT-moduline disinhibits serotonin release and may have antidepressant potential. Antibodies and small-molecule antagonists against 5-HT-moduline like HG1 have been found to produce anxiolytic-like effects in rodents. 5-HT-moduline was first described in the scientific literature by 1996. Analogues of 5-HT-moduline have been studied.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «5-HT-moduline» — https://en.wikipedia.org/wiki/5-HT-moduline
Wikidata Q82240232: «composto chimico» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q82240232
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/5-HT-moduline?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1377740874, consultata il 2026-11-06T17:24:11.860Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 799810fd79b31eb9b67bbe06a2f6fed91cc809abda44cc09acc4e464b5cbd77f