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Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter — Europe PMC PMID:37458712

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/37458712
DOI: 10.1289/ehp12259
License (as archived): CC0-1.0
Archived: 2026-10-07T12:57:57.064Z
SHA-256 of the archived text: b8abaf2e6b8cbd60b18437c5f9896d657c63b066327ad577537352f093b8f70b
Stable URL of this page: https://metraipolis.com/documento/dc_7fa52229f264

How to cite

Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter — Europe PMC PMID:37458712 — Europe PMC (en), https://europepmc.org/article/MED/37458712 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_7fa52229f264 (Metraipolis archive dc_7fa52229f264, sha256 b8abaf2e6b8cbd60b18437c5f9896d657c63b066327ad577537352f093b8f70b)

BibTeX

@misc{dc7fa52229f264,
  title = {Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter — Europe PMC PMID:37458712},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/37458712},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_7fa52229f264; sha256 b8abaf2e6b8cbd60b18437c5f9896d657c63b066327ad577537352f093b8f70b},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/37458712. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Chronic lung injury and dysregulated cellular homeostasis in response to particulate matter (PM) exposure are closely associated with adverse health effects. However, an effective intervention for preventing the adverse health effects has not been developed. Objectives: This study aimed to evaluate the protective effects of nicotinamide mononucleotide (NMN) supplementation on lung injury and elucidate the mechanism by which NMN improved immune function following subchronic PM exposure. Methods: Six-week-old male C57BL/6J mice were placed in a real-ambient PM exposure system or filtered air-equipped chambers (control) for 16 wk with or without NMN supplementation in drinking water (regarded as Con-H2O, Exp-H2O, Con-NMN and Exp-NMN groups, respectively) in Shijiazhuang City, China (n=20/group). The effects of NMN supplementation (500mg/kg) on PM-induced chronic pulmonary inflammation were assessed, and its mechanism was characterized using single-cell transcriptomic sequencing (scRNA-seq) analysis of whole lung cells. Results: The NMN-treated mice exhibited higher NAD+ levels in multiple tissues. Following 16-wk PM exposure, slightly less pulmonary inflammation and less collagen deposition were noted in mice with NMN supplementation in response to real-ambient PM exposure (Exp-NMN group) compared with the Exp-H2O group (all p<0.05). Mouse lung tissue isolated from the Exp-NMN group was characterized by fewer neutrophils, monocyte-derived cells, fibroblasts, and myeloid-derived suppressor cells induced by subchronic PM exposure as detected by scRNA-seq transcriptomic analysis. The improved immune functions were further characterized by interleukin-17 signaling pathway inhibition and lower secretion of profibrotic cytokines in the Exp-NMN group compared with the Exp-H2O group. In addition, reduced proportions of differentiated myofibroblasts and profibrotic interstitial macrophages were identified in the NMN-supplemented mice in response to PM exposure. Furthermore, less immune function suppression and altered differentiation of pathological cell phenotypes NMN was related to intracellular lipid metabolism activation. Discussion: Our novel findings suggest that NMN supplementation mitigated PM-induced lung injury by regulating immune functions and improving lipid metabolism in male mice, providing a putative intervention method for prevention of human health effects associated with PM exposure. https://doi.org/10.1289/EHP12259.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2023 (prima pubblicazione 2023-07-17).
Identificativi: PMID 37458712 · PMCID PMC10351503 · DOI 10.1289/ehp12259.
Descrittori MeSH principali: Pneumonia; Lung Injury.
Pagina: https://europepmc.org/article/MED/37458712 — https://doi.org/10.1289/ehp12259. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
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