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An economic evaluation of the Whole Genome Sequencing source tracking program in the U.S — Europe PMC PMID:34614029

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34614029
DOI: 10.1371/journal.pone.0258262
License (as archived): CC0-1.0
Archived: 2026-11-02T13:10:51.689Z
SHA-256 of the archived text: 318004102b50358530a6b04e0604b9b08e4298fe724035db22a75915b2bc1905
Stable URL of this page: https://metraipolis.com/documento/dc_7dff10e340ea

How to cite

An economic evaluation of the Whole Genome Sequencing source tracking program in the U.S — Europe PMC PMID:34614029 — Europe PMC (en), https://europepmc.org/article/MED/34614029 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_7dff10e340ea (Metraipolis archive dc_7dff10e340ea, sha256 318004102b50358530a6b04e0604b9b08e4298fe724035db22a75915b2bc1905)

BibTeX

@misc{dc7dff10e340ea,
  title = {An economic evaluation of the Whole Genome Sequencing source tracking program in the U.S — Europe PMC PMID:34614029},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34614029},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_7dff10e340ea; sha256 318004102b50358530a6b04e0604b9b08e4298fe724035db22a75915b2bc1905},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34614029. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

The U.S. Food and Drug Administration (FDA) created the GenomeTrakr Whole Genome Sequencing (WGS) Network in 2013, as a tool to improve food safety. This study presents an analysis of Whole Genome source tracking implementation on potential food contamination and related illnesses through theoretical, empirical, and cost benefit analyses. We conduct empirical tests using data from FDA regulated food commodity outbreaks garnering FDA response from 1999 through 2019 and examine the effect of the National Center for Biotechnology Information (NCBI) Pathogen detection program of source tracking WGS isolates collected in the U.S. on outbreak illnesses for three pilot pathogens (E. coli, Listeria, and Salmonella). Empirical results are consistent with the theoretical model and suggest that each additional 1,000 WGS isolates added to the public NCBI database is associated with a reduction of approximately 6 illnesses per WGS pathogen, per year. Empirical results are connected to existing literature for a Monte Carlo analysis to estimate benefits and costs. By 2019, annual health benefits are estimated at nearly $500 million, compared to an approximately $22 million investment by public health agencies. Even under conservative assumptions, the program likely broke even in its second year of implementation and could produce increasing public health benefits as the GenomeTrakr network matures.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-10-06).
Identificativi: PMID 34614029 · PMCID PMC8494326 · DOI 10.1371/journal.pone.0258262.
Pagina: https://europepmc.org/article/MED/34614029 — https://doi.org/10.1371/journal.pone.0258262. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-02T13:02:58.555Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.