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Acanthosis nigricans-muscle cramps-acral enlargement syndrome — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Acanthosis_nigricans-muscle_cramps-acral_enlargement_syndrome
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-07T09:54:21.906Z
SHA-256 of the archived text: 76e459fded3d70bbb49eaa18ef411badd555ebe466770e542eb2b3e2ab23505c
Stable URL of this page: https://metraipolis.com/documento/dc_7aadc55bc2ee

How to cite

Acanthosis nigricans-muscle cramps-acral enlargement syndrome — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Acanthosis_nigricans-muscle_cramps-acral_enlargement_syndrome (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_7aadc55bc2ee (Metraipolis archive dc_7aadc55bc2ee, sha256 76e459fded3d70bbb49eaa18ef411badd555ebe466770e542eb2b3e2ab23505c)

BibTeX

@misc{dc7aadc55bc2ee,
  title = {Acanthosis nigricans-muscle cramps-acral enlargement syndrome — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Acanthosis_nigricans-muscle_cramps-acral_enlargement_syndrome},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_7aadc55bc2ee; sha256 76e459fded3d70bbb49eaa18ef411badd555ebe466770e542eb2b3e2ab23505c},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Acanthosis_nigricans-muscle_cramps-acral_enlargement_syndrome. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Acanthosis nigricans-muscle cramps-acral enlargement syndrome, also known as Acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome, is an extremely rare genetic disorder which is characterized by the appearance of acanthosis nigricans, insulin resistance, muscle cramps of severe intensity, and acral hypertrophy/enlargement. Only 2 cases have been reported in medical literature. It was first discovered when Jeffrey Flier and his colleagues described two siblings of the opposite sex with the symptoms mentioned above. (plus: large, chunky hands), the sister had virilized polycystic ovaries. After being treated with dilantin, the cramps' severity lowered and the brother's insulin resistance also lowered. The inheritance pattern of this disorder is thought to be autosomal recessive.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «Acanthosis nigricans-muscle cramps-acral enlargement syndrome» — https://en.wikipedia.org/wiki/Acanthosis_nigricans-muscle_cramps-acral_enlargement_syndrome
Wikidata Q55998504: «This syndrome is characterised by the association of acanthosis nigricans, insulin resistance, severe muscle cramps and acral hypertrophy» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q55998504
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Acanthosis_nigricans-muscle_cramps-acral_enlargement_syndrome?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1369518541, consultata il 2026-11-07T09:49:55.294Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 17c1d59388c777669d1d9f3107fa47bb47640b2e15467ce494090aa32709aeaf