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Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort — Europe PMC PMID:31808705

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31808705
DOI: 10.1289/ehp5057
License (as archived): CC0-1.0
Archived: 2026-11-09T23:53:12.015Z
SHA-256 of the archived text: 693b5bc06c65e269f5e4075facc0313efcfda51790f44b61276c22cb778a59ef
Stable URL of this page: https://metraipolis.com/documento/dc_78ca42e7b79b

How to cite

Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort — Europe PMC PMID:31808705 — Europe PMC (en), https://europepmc.org/article/MED/31808705 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_78ca42e7b79b (Metraipolis archive dc_78ca42e7b79b, sha256 693b5bc06c65e269f5e4075facc0313efcfda51790f44b61276c22cb778a59ef)

BibTeX

@misc{dc78ca42e7b79b,
  title = {Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort — Europe PMC PMID:31808705},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31808705},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_78ca42e7b79b; sha256 693b5bc06c65e269f5e4075facc0313efcfda51790f44b61276c22cb778a59ef},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31808705. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. Objectives: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrations and the prevalence of atherosclerotic plaque in the carotid artery. Methods: We used cross-sectional data from the Malmö Diet and Cancer Study cardiovascular cohort (MDCS-CC; recruitment in 1991-1994) covering 4,172 middle-aged men and women. B-Pb at baseline, measured by inductively coupled plasma mass spectrometry, was used as the exposure biomarker. The presence of atherosclerotic plaque in the carotid artery was determined by B-mode ultrasonography. We used logistic regression to estimate odds ratios (ORs) for prevalence of plaque in the carotid artery according to B-Pb quartiles. Results: The median B-Pb was 25μg/L (range: 1.5-258), and 36% of the cohort had any atherosclerotic plaque. After controlling for confounders and known cardiovascular risk factors, the OR for prevalence of plaque in the highest quartile (Q4) of B-Pb compared with the lowest quartile (Q1) was 1.35 (95% CI: 1.09, 1.66) in the total group, 1.58 (95% CI: 1.20, 2.08) among women, and 1.18 (95% CI: 0.83, 1.69) among men. Among women, associations were limited to those who were postmenopausal [OR for Q4 vs. Q1=1.72 (95% CI: 1.26, 2.34) vs. OR=0.96 (95% CI: 0.49, 1.89 in premenopausal women)]. Associations were weak and nonsignificant in never-smokers [OR for Q4 vs. Q1=1.14 (95% CI: 0.81, 1.61)]. Discussion: Our study shows an association between B-Pb concentrations and occurrence of atherosclerotic plaque in the carotid artery, adding evidence for an underlying pro-atherogenic role of lead in cardiovascular disease. Associations appeared to be limited to postmenopausal (vs. premenopausal) women. https://doi.org/10.1289/EHP5057.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2019 (prima pubblicazione 2019-12-06).
Identificativi: PMID 31808705 · PMCID PMC6957277 · DOI 10.1289/ehp5057.
Descrittori MeSH principali: Carotid Arteries.
Pagina: https://europepmc.org/article/MED/31808705 — https://doi.org/10.1289/ehp5057. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-09T23:50:29.493Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.