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Trough level — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Trough_level
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-08T00:11:29.107Z
SHA-256 of the archived text: ed2d790a9205adcefedcc1c60ba6ee9918053c54a6662920bf98a234f993a74a
Stable URL of this page: https://metraipolis.com/documento/dc_76ac82a992cd

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Trough level — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Trough_level (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_76ac82a992cd (Metraipolis archive dc_76ac82a992cd, sha256 ed2d790a9205adcefedcc1c60ba6ee9918053c54a6662920bf98a234f993a74a)

BibTeX

@misc{dc76ac82a992cd,
  title = {Trough level — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Trough_level},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_76ac82a992cd; sha256 ed2d790a9205adcefedcc1c60ba6ee9918053c54a6662920bf98a234f993a74a},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Trough_level. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

In medicine and pharmacology, a trough level or trough concentration (Ctrough) is the concentration reached by a drug immediately before the next dose is administered, often used in therapeutic drug monitoring. The name comes from the idea that on a graph of concentration versus time, the line forms a U-shaped trough at the lowest region, before a new dose sends it higher again. The usual criterion is concentration in the blood serum, although in some instances local concentration within tissues is relevant. It is pharmacokinetically normal that over time, the drug molecules are being metabolized or cleared by the body, so the concentration of drug that remains available is dropping. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. A trough level is contrasted with a "peak level" (Cmax), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is widely used in clinical trials for newer medicines to investigate therapeutic effectiveness and safety. Ctrough is slightly different from Cmin, the minimum concentration during the time interval between administration of two doses.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; ricerca «pharmacology»).
Fonte: Wikipedia in inglese, voce «Trough level» — https://en.wikipedia.org/wiki/Trough_level
Wikidata Q7846541 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q7846541
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Trough_level?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1247897750, consultata il 2026-10-07T23:41:33.893Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 05cc70b6e4b049cf2ac0bf160dec03ff9ac020a56ebc3dd9ba367514e0fe8849