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Vertical transmission of HIV among pregnant women who initially had false-negative rapid HIV tests in four South African antenatal clinics — Europe PMC PMID:31860677

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31860677
DOI: 10.1371/journal.pone.0226391
License (as archived): CC0-1.0
Archived: 2026-11-09T21:07:52.235Z
SHA-256 of the archived text: faafed97f9ec0961857ba471284bb1e4564b345a3eec7b6a00cdce095d4317e6
Stable URL of this page: https://metraipolis.com/documento/dc_7488ce2caae8

How to cite

Vertical transmission of HIV among pregnant women who initially had false-negative rapid HIV tests in four South African antenatal clinics — Europe PMC PMID:31860677 — Europe PMC (en), https://europepmc.org/article/MED/31860677 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_7488ce2caae8 (Metraipolis archive dc_7488ce2caae8, sha256 faafed97f9ec0961857ba471284bb1e4564b345a3eec7b6a00cdce095d4317e6)

BibTeX

@misc{dc7488ce2caae8,
  title = {Vertical transmission of HIV among pregnant women who initially had false-negative rapid HIV tests in four South African antenatal clinics — Europe PMC PMID:31860677},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31860677},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_7488ce2caae8; sha256 faafed97f9ec0961857ba471284bb1e4564b345a3eec7b6a00cdce095d4317e6},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31860677. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Introduction: There is a risk of mother-to-child transmission of HIV (MTCT) during pregnancy and breastfeeding. The aim of this study was to assess vertical transmission of HIV among pregnant women who initially had false-negative rapid HIV tests in South African antenatal care (ANC) clinics. Methods: Pregnant participants were enrolled in a diagnostic study that used nucleic acid amplification testing (NAAT) to screen for early HIV infection among individuals who tested negative on rapid HIV tests used at the point-of-care (POC) facilities. Participants were enrolled from four ANC clinics in the Tshwane district of South Africa. All NAAT-positive participants were recalled to the clinics for further management. Vertical transmission was assessed among exposed infants whose HIV polymerase chain reaction (PCR) results were available. Results: This study enrolled 8208 pregnant participants who tested negative on rapid HIV tests between 2013 and 2016. Their median age was 26 years (interquartile range [IQR]: 23-30). NAAT detected HIV infections in 0.6% (n = 49; 95% confidence interval {CI}: 0.5-0.8) of all study participants. The distribution of these infections among the four clinics ranged from 0.3%- 1.1%, but this was not statistically significant (p = 0.07). Forty-seven participants (95.9%) were successfully recalled and referred for antiretroviral treatment initiation as part of prevention of MTCT (PMTCT). Most women with newly diagnosed HIV infection presented for the first ANC visit in the second (61.9%, n = 26) and third (31.0%, n = 13) trimesters. HIV PCR results were available for thirty-two infants, three of whom tested positive (9.4%; 95% CI: 1.98-25.02). Conclusions: This study showed that supplemental HIV testing for pregnant women led to earlier linkage to the PMTCT programme. Inaccurate diagnosis of HIV infection at ANC clinics is likely to undermine the efforts of eliminating MTCT particularly in HIV-endemic settings.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2019 (prima pubblicazione 2019-12-20).
Identificativi: PMID 31860677 · PMCID PMC6924658 · DOI 10.1371/journal.pone.0226391.
Pagina: https://europepmc.org/article/MED/31860677 — https://doi.org/10.1371/journal.pone.0226391. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
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