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Activation mapping in multi-center rat sensory-evoked functional MRI datasets using a unified pipeline — Europe PMC PPR:PPR917829

Source: Europe PMC
Original: https://europepmc.org/article/PPR/PPR917829
DOI: 10.1101/2024.09.27.615384
License (as archived): CC0-1.0
Archived: 2026-10-06T15:19:20.393Z
SHA-256 of the archived text: 0383ae3cf8f1ba9c5b132015a1db195beef9bd7175376d94d1d6cd4a02cf5269
Stable URL of this page: https://metraipolis.com/documento/dc_720cf2c7ea69

How to cite

Activation mapping in multi-center rat sensory-evoked functional MRI datasets using a unified pipeline — Europe PMC PPR:PPR917829 — Europe PMC, https://europepmc.org/article/PPR/PPR917829 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_720cf2c7ea69 (Metraipolis archive dc_720cf2c7ea69, sha256 0383ae3cf8f1ba9c5b132015a1db195beef9bd7175376d94d1d6cd4a02cf5269)

BibTeX

@misc{dc720cf2c7ea69,
  title = {Activation mapping in multi-center rat sensory-evoked functional MRI datasets using a unified pipeline — Europe PMC PPR:PPR917829},
  howpublished = {Europe PMC},
  url = {https://europepmc.org/article/PPR/PPR917829},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_720cf2c7ea69; sha256 0383ae3cf8f1ba9c5b132015a1db195beef9bd7175376d94d1d6cd4a02cf5269},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC, https://europepmc.org/article/PPR/PPR917829. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Functional Magnetic Resonance Imaging (fMRI) in rodents is pivotal for understanding the mechanisms underlying Blood Oxygen Level-Dependent (BOLD) signals and phenotyping animal models of disorders, amongst other applications. Despite its growing use, comparing rodent fMRI results across different research sites remains challenging due to variations in experimental protocols. Here, we aggregated and analyzed 22 sensory-evoked rat fMRI datasets from 12 imaging centers, totaling scans from 220 rats, to assess the consistency of results across diverse protocols. We applied a standardized preprocessing pipeline and evaluated the impact of different hemodynamic response function models on group and individual level activity patterns. Our analysis revealed inter-dataset variability attributed to differences in experimental design, anesthesia protocols, and imaging parameters. We identified robust activation clusters in all (22/22) datasets. The comparison between stock human models implemented in software and rat-specific models showed significant variations in the resulting statistical maps. Our findings emphasize the necessity for standardized protocols and collaborative efforts to improve the reproducibility and reliability of rodent fMRI studies. We provide open access to all datasets and analysis code to foster transparency and further research in the field.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: bioRxiv, 2024 (prima pubblicazione 2024-09-30).
Identificativi: DOI 10.1101/2024.09.27.615384.
Pagina: https://europepmc.org/article/PPR/PPR917829 — https://doi.org/10.1101/2024.09.27.615384. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T15:11:56.385Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.