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ACBI3 — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/ACBI3
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-06T23:32:57.347Z
SHA-256 of the archived text: 83b42eb8d1a3de93144f765f816100b11ee6cb5823c2dc4e6911b345bfb259df
Stable URL of this page: https://metraipolis.com/documento/dc_6ff35d47fd8a

How to cite

ACBI3 — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/ACBI3 (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_6ff35d47fd8a (Metraipolis archive dc_6ff35d47fd8a, sha256 83b42eb8d1a3de93144f765f816100b11ee6cb5823c2dc4e6911b345bfb259df)

BibTeX

@misc{dc6ff35d47fd8a,
  title = {ACBI3 — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/ACBI3},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_6ff35d47fd8a; sha256 83b42eb8d1a3de93144f765f816100b11ee6cb5823c2dc4e6911b345bfb259df},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/ACBI3. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

ACBI3 is an experimental anticancer agent which is one of the first examples of a proteolysis targeting chimera (PROTAC) against the protein KRAS. Being a PROTAC, it is a bifunctional molecule with two halves joined by a linker; one half binds to its target, KRAS which is a key driver in certain types of cancer, while the other half binds E3 ligase which triggers the cell's natural protein degradation mechanisms. This causes the KRAS protein to be degraded. In early stage testing, it was able to target 13 of the 17 most common mutated forms of KRAS found in cancer cells, allowing selective targeting of a wide range of cancer types. While this particular molecule is still at an early developmental stage, it is an important proof of concept that KRAS can be targeted with a PROTAC.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «ACBI3» — https://en.wikipedia.org/wiki/ACBI3
Wikidata Q133278582: «experimental anticancer drug» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q133278582
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/ACBI3?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1382838141, consultata il 2026-11-06T23:29:35.264Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 5dac11d171abc467a1f850a2100307f230a4e505bbcf548a6117cbb8ac9fbb41