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Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques — Europe PMC PMID:32453728

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32453728
DOI: 10.1371/journal.pbio.3000605
License (as archived): CC0-1.0
Archived: 2026-11-08T16:02:06.593Z
SHA-256 of the archived text: c3b072259589dab2f5f9dfeff17e34772a4cc07da11ec42f1c3f9d731a291bf6
Stable URL of this page: https://metraipolis.com/documento/dc_6c707a67cae2

How to cite

Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques — Europe PMC PMID:32453728 — Europe PMC (en), https://europepmc.org/article/MED/32453728 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_6c707a67cae2 (Metraipolis archive dc_6c707a67cae2, sha256 c3b072259589dab2f5f9dfeff17e34772a4cc07da11ec42f1c3f9d731a291bf6)

BibTeX

@misc{dc6c707a67cae2,
  title = {Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques — Europe PMC PMID:32453728},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32453728},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_6c707a67cae2; sha256 c3b072259589dab2f5f9dfeff17e34772a4cc07da11ec42f1c3f9d731a291bf6},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32453728. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

One of the most influential accounts of central orbitofrontal cortex-that it mediates behavioral flexibility-has been challenged by the finding that discrimination reversal in macaques, the classic test of behavioral flexibility, is unaffected when lesions are made by excitotoxin injection rather than aspiration. This suggests that the critical brain circuit mediating behavioral flexibility in reversal tasks lies beyond the central orbitofrontal cortex. To determine its identity, a group of nine macaques were taught discrimination reversal learning tasks, and its impact on gray matter was measured. Magnetic resonance imaging scans were taken before and after learning and compared with scans from two control groups, each comprising 10 animals. One control group learned discrimination tasks that were similar but lacked any reversal component, and the other control group engaged in no learning. Gray matter changes were prominent in posterior orbitofrontal cortex/anterior insula but were also found in three other frontal cortical regions: lateral orbitofrontal cortex (orbital part of area 12 [12o]), cingulate cortex, and lateral prefrontal cortex. In a second analysis, neural activity in posterior orbitofrontal cortex/anterior insula was measured at rest, and its pattern of coupling with the other frontal cortical regions was assessed. Activity coupling increased significantly in the reversal learning group in comparison with controls. In a final set of experiments, we used similar structural imaging procedures and analyses to demonstrate that aspiration lesion of central orbitofrontal cortex, of the type known to affect discrimination learning, affected structure and activity in the same frontal cortical circuit. The results identify a distributed frontal cortical circuit associated with behavioral flexibility.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS biology, 2020 (prima pubblicazione 2020-05-26).
Identificativi: PMID 32453728 · PMCID PMC7274449 · DOI 10.1371/journal.pbio.3000605.
Pagina: https://europepmc.org/article/MED/32453728 — https://doi.org/10.1371/journal.pbio.3000605. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-08T15:58:26.159Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.