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Phylogeographic analysis of Pseudogymnoascus destructans partitivirus-pa explains the spread dynamics of white-nose syndrome in North America — Europe PMC PMID:33730096

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33730096
DOI: 10.1371/journal.ppat.1009236
License (as archived): CC0-1.0
Archived: 2026-11-05T13:13:16.132Z
SHA-256 of the archived text: 57b719587edbd540036d4d03e83817483572b8ae38297dd48cc3f7d95a3f87f3
Stable URL of this page: https://metraipolis.com/documento/dc_6aa8ebddafee

How to cite

Phylogeographic analysis of Pseudogymnoascus destructans partitivirus-pa explains the spread dynamics of white-nose syndrome in North America — Europe PMC PMID:33730096 — Europe PMC (en), https://europepmc.org/article/MED/33730096 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_6aa8ebddafee (Metraipolis archive dc_6aa8ebddafee, sha256 57b719587edbd540036d4d03e83817483572b8ae38297dd48cc3f7d95a3f87f3)

BibTeX

@misc{dc6aa8ebddafee,
  title = {Phylogeographic analysis of Pseudogymnoascus destructans partitivirus-pa explains the spread dynamics of white-nose syndrome in North America — Europe PMC PMID:33730096},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33730096},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_6aa8ebddafee; sha256 57b719587edbd540036d4d03e83817483572b8ae38297dd48cc3f7d95a3f87f3},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33730096. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Understanding the dynamics of white-nose syndrome spread in time and space is an important component for the disease epidemiology and control. We reported earlier that a novel partitivirus, Pseudogymnoascus destructans partitivirus-pa, had infected the North American isolates of Pseudogymnoascus destructans, the fungal pathogen that causes white-nose syndrome in bats. We showed that the diversity of the viral coat protein sequences is correlated to their geographical origin. Here we hypothesize that the geographical adaptation of the virus could be used as a proxy to characterize the spread of white-nose syndrome. We used over 100 virus isolates from diverse locations in North America and applied the phylogeographic analysis tool BEAST to characterize the spread of the disease. The strict clock phylogeographic analysis under the coalescent model in BEAST showed a patchy spread pattern of white-nose syndrome driven from a few source locations including Connecticut, New York, West Virginia, and Kentucky. The source states had significant support in the maximum clade credibility tree and Bayesian stochastic search variable selection analysis. Although the geographic origin of the virus is not definite, it is likely the virus infected the fungus prior to the spread of white-nose syndrome in North America. We also inferred from the BEAST analysis that the recent long-distance spread of the fungus to Washington had its root in Kentucky, likely from the Mammoth cave area and most probably mediated by a human. The time to the most recent common ancestor of the virus is estimated somewhere between the late 1990s to early 2000s. We found the mean substitution rate of 2 X 10-3 substitutions per site per year for the virus which is higher than expected given the persistent lifestyle of the virus, and the stamping-machine mode of replication. Our approach of using the virus as a proxy to understand the spread of white-nose syndrome could be an important tool for the study and management of other infectious diseases.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2021 (prima pubblicazione 2021-03-17).
Identificativi: PMID 33730096 · PMCID PMC7968715 · DOI 10.1371/journal.ppat.1009236.
Descrittori MeSH principali: Phylogeography.
Pagina: https://europepmc.org/article/MED/33730096 — https://doi.org/10.1371/journal.ppat.1009236. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-05T13:07:28.227Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.