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Membranome database — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Membranome_database
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-06T14:04:40.031Z
SHA-256 of the archived text: 5a3408c7d857ba3fa72f71eee7496cae8b8f25d9131a49631b427e95a1ea4fa6
Stable URL of this page: https://metraipolis.com/documento/dc_65bf894ea4fc

How to cite

Membranome database — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Membranome_database (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_65bf894ea4fc (Metraipolis archive dc_65bf894ea4fc, sha256 5a3408c7d857ba3fa72f71eee7496cae8b8f25d9131a49631b427e95a1ea4fa6)

BibTeX

@misc{dc65bf894ea4fc,
  title = {Membranome database — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Membranome_database},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_65bf894ea4fc; sha256 5a3408c7d857ba3fa72f71eee7496cae8b8f25d9131a49631b427e95a1ea4fa6},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Membranome_database. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Membranome database provides structural and functional information about more than 6000 single-pass (bitopic) transmembrane proteins from Homo sapiens, Arabidopsis thaliana, Dictyostelium discoideum, Saccharomyces cerevisiae, Escherichia coli and Methanocaldococcus jannaschii. Bitopic membrane proteins consist of a single transmembrane alpha-helix connecting water-soluble domains of the protein situated at the opposite sides of a biological membrane. These proteins are frequently involved in the signal transduction and communication between cells in multicellular organisms. The database provides information about the individual proteins including computationally generated three-dimensional models of their transmembrane alpha-helices spatially arranged in the membrane, topology, intracellular localizations, amino acid sequences, domain architecture, functional annotation and available experimental structures from the Protein Data Bank. It also provides a classification of bitopic proteins into 15 functional classes, more than 700 structural superfamilies and 1400 families, along with 3D structures of bitopic protein complexes which are also classified to different families. The second Membranome version provides 3D models of more than 2000 parallel homodimers formed by TM α-helices of bitopic proteins from different organisms which were generated using TMDOCK program. The models of the homodimers were verified through comparison with available experimental data for nearly 600 proteins. The database includes downloadable coordinate files of transmembrane helices and their homodimers with calculated membrane boundaries. Membranome 3.0 version incorporates models generated by AlphaFold 2. The database website provides access to related webservers, FMAP and TMDOCK which have been developed for modeling individual alpha-helices and their dimeric complexes in membranes. The database and webservers were used in experimental and bioinformatics studies of bitopic membrane proteins

Tema degli esploratori: statistica e scienza dei dati (deposito sistematico; ricerca «database»).
Fonte: Wikipedia in inglese, voce «Membranome database» — https://en.wikipedia.org/wiki/Membranome_database
Wikidata Q55641049: «Online database of protein» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q55641049
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Membranome_database?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1313841339, consultata il 2026-10-06T12:24:05.630Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: c2483f5e3263edaa445e617318ea1a0b3ee03c6b9a9307992373634496f3c725