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Modeling effectiveness of testing strategies to prevent COVID-19 in nursing homes —United States, 2020 — Europe PMC PPR:PPR256285

Source: Europe PMC
Original: https://europepmc.org/article/PPR/PPR256285
DOI: 10.1101/2020.12.18.20248255
License (as archived): CC0-1.0
Archived: 2026-11-06T13:01:03.356Z
SHA-256 of the archived text: 7bcd031efaf662c2357a107d1c099d482651e90f9d56720c8abe896d9796bf66
Stable URL of this page: https://metraipolis.com/documento/dc_654fbb0bf91f

How to cite

Modeling effectiveness of testing strategies to prevent COVID-19 in nursing homes —United States, 2020 — Europe PMC PPR:PPR256285 — Europe PMC, https://europepmc.org/article/PPR/PPR256285 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_654fbb0bf91f (Metraipolis archive dc_654fbb0bf91f, sha256 7bcd031efaf662c2357a107d1c099d482651e90f9d56720c8abe896d9796bf66)

BibTeX

@misc{dc654fbb0bf91f,
  title = {Modeling effectiveness of testing strategies to prevent COVID-19 in nursing homes —United States, 2020 — Europe PMC PPR:PPR256285},
  howpublished = {Europe PMC},
  url = {https://europepmc.org/article/PPR/PPR256285},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_654fbb0bf91f; sha256 7bcd031efaf662c2357a107d1c099d482651e90f9d56720c8abe896d9796bf66},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC, https://europepmc.org/article/PPR/PPR256285. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: SARS-CoV-2 outbreaks in nursing homes can be large with high case fatality. Identifying asymptomatic individuals early through serial testing is recommended to control COVID-19 in nursing homes, both in response to an outbreak (“outbreak testing” of residents and healthcare personnel) and in facilities without outbreaks (“non-outbreak testing” of healthcare personnel). The effectiveness of outbreak testing and isolation with or without non-outbreak testing was evaluated. Methods: Using published SARS-CoV-2 transmission parameters, the fraction of SARS-CoV-2 transmissions prevented through serial testing (weekly, every three days, or daily) and isolation of asymptomatic persons compared to symptom-based testing and isolation was evaluated through mathematical modeling using a Reed-Frost model to estimate the percentage of cases prevented (i.e., “effectiveness”) through either outbreak testing alone or outbreak plus non-outbreak testing. The potential effect of simultaneous decreases (by 10%) in the effectiveness of isolating infected individuals when instituting testing strategies was also evaluated. Results: Modeling suggests that outbreak testing could prevent 54% (weekly testing with 48-hour test turnaround) to 92% (daily testing with immediate results and 50% relative sensitivity) of SARS-CoV-2 infections. Adding non-outbreak testing could prevent up to an additional 8% of SARS-CoV-2 infections (depending on test frequency and turnaround time). However, added benefits of non-outbreak testing were mostly negated if accompanied by decreases in infection control practice. Conclusions: When combined with high-quality infection control practices, outbreak testing could be an effective approach to preventing COVID-19 in nursing homes, particularly if optimized through increased test frequency and use of tests with rapid turnaround. Summary: Mathematical modeling evaluated the effectiveness of serially testing asymptomatic persons in a nursing home in response to a SARS-CoV-2 outbreak with or without serial testing of asymptomatic staff in the absence of known SARS-CoV-2 infections.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: medRxiv, 2020 (prima pubblicazione 2020-12-22).
Identificativi: DOI 10.1101/2020.12.18.20248255.
Pagina: https://europepmc.org/article/PPR/PPR256285 — https://doi.org/10.1101/2020.12.18.20248255. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-06T12:57:15.630Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.