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HIV risk behaviour, viraemia, and transmission across HIV cascade stages including low-level viremia: Analysis of 14 cross-sectional population-based HIV… — Europe PMC PMID:38573931

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/38573931
DOI: 10.1371/journal.pgph.0003030
License (as archived): CC0-1.0
Archived: 2026-10-06T20:05:35.017Z
SHA-256 of the archived text: f6caaf916e4b2844f56334d98c79624a72e08525554ccd71b692cc65462f3b5c
Stable URL of this page: https://metraipolis.com/documento/dc_651908db498c

How to cite

HIV risk behaviour, viraemia, and transmission across HIV cascade stages including low-level viremia: Analysis of 14 cross-sectional population-based HIV… — Europe PMC PMID:38573931 — Europe PMC (en), https://europepmc.org/article/MED/38573931 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_651908db498c (Metraipolis archive dc_651908db498c, sha256 f6caaf916e4b2844f56334d98c79624a72e08525554ccd71b692cc65462f3b5c)

BibTeX

@misc{dc651908db498c,
  title = {HIV risk behaviour, viraemia, and transmission across HIV cascade stages including low-level viremia: Analysis of 14 cross-sectional population-based HIV… — Europe PMC PMID:38573931},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/38573931},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_651908db498c; sha256 f6caaf916e4b2844f56334d98c79624a72e08525554ccd71b692cc65462f3b5c},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/38573931. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

As antiretroviral treatment (ART) coverage for people living with HIV (PLHIV) increases, HIV programmes require up-to-date information about evolving HIV risk behaviour and transmission risk, including those with low-level viremia (LLV; >50 to ≤1000 copies/mL), to guide prevention priorities. We aimed to assess differences in sexual risk behaviours, distribution of viral load (VL) and proportion of transmission across PLHIV subgroups. We analysed data from Population-based HIV Impact Assessment surveys in 14 sub-Saharan African countries during 2015-2019. We estimated adjusted prevalence ratios (aPR) of self-reported HIV high-risk behaviour (multiple partners and condomless sex) across cascade stages via generalised estimation equations. We modelled the proportions of transmission from each subgroup using relative self-reported sexual risk, a Hill function for transmission rate by VL, and proportions within cascade stages from surveys and UNAIDS country estimates for 2010-2020. Compared to PLHIV with undetectable VL (≤50 copies/mL), undiagnosed PLHIV (aPR women: 1.28 [95% CI: 1.08-1.52]; men: 1.61 [1.33-1.95]) and men diagnosed but untreated (2.06 [1.52-2.78]) were more likely to self-report high-risk sex. High-risk behaviour was not significantly associated with LLV. Mean VL was similar among undiagnosed, diagnosed but untreated, and on ART but non-suppressed sub-groups. Across surveys, undiagnosed and diagnosed but untreated contributed most to transmission (40-91% and 1-41%, respectively), with less than 1% from those with LLV. Between 2010 and 2020, the proportion of transmission from individuals on ART but non-suppressed increased. In settings with high ART coverage, effective HIV testing, ART linkage, and retention remain priorities to reduce HIV transmission. Persons with LLV are an increasing share of PLHIV but their contribution to HIV transmission was small. Improving suppression among PLHIV on ART with VL ≥1000 copies/mL will become increasingly important.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLOS global public health, 2024 (prima pubblicazione 2024-04-04).
Identificativi: PMID 38573931 · PMCID PMC10994324 · DOI 10.1371/journal.pgph.0003030.
Pagina: https://europepmc.org/article/MED/38573931 — https://doi.org/10.1371/journal.pgph.0003030. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
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