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Evaluation of Sub-acute toxicity and safety profile of Charmagaz seed oil in rats — Europe PMC PMID:40644426

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40644426
DOI: 10.1371/journal.pone.0327697
License (as archived): CC0-1.0
Archived: 2026-10-06T09:45:22.858Z
SHA-256 of the archived text: 104f0eab36022997657ef163002df6e457b7355529e097b58cd33bec604ccba2
Stable URL of this page: https://metraipolis.com/documento/dc_64dfebdcb36b

How to cite

Evaluation of Sub-acute toxicity and safety profile of Charmagaz seed oil in rats — Europe PMC PMID:40644426 — Europe PMC (en), https://europepmc.org/article/MED/40644426 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_64dfebdcb36b (Metraipolis archive dc_64dfebdcb36b, sha256 104f0eab36022997657ef163002df6e457b7355529e097b58cd33bec604ccba2)

BibTeX

@misc{dc64dfebdcb36b,
  title = {Evaluation of Sub-acute toxicity and safety profile of Charmagaz seed oil in rats — Europe PMC PMID:40644426},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40644426},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_64dfebdcb36b; sha256 104f0eab36022997657ef163002df6e457b7355529e097b58cd33bec604ccba2},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40644426. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Charmagaz seed oil (CSO), derived from Cucurbitaceae family, and is a traditional mix of four different seeds: pumpkin, cucumber, watermelon, and musk melon. Widely utilized in Asia, this blend is considered as a brain tonic and a nutritional powerhouse. Despite its significant ethno medicinal value, the potential toxicity and safety of this combination oil have not been scientifically documented. Therefore, the current study was conducted to assess the sub-acute toxicity of Charmagaz seed oil in rat model for the assessment of its safety profile. For acute oral toxicity CSO was given at doses of 50, 500, and 5000 mg/kg orally over 28 days in rats. No evidence of toxicity was observed in animals when acutely exposed to CSO, implying that the LD50 is higher than 5000 mg/kg body weight. Cell viability assay revealed that Charmagaz oil is relatively non-toxic, showing an inhibition rate below 50% following 24 and 48-hour exposures. In the Brine Shrimp bioassay, oil demonstrated no cytotoxic effects, unlike the standard cytotoxic drug Etoposide, which resulted in 70% mortality at a 7.5 μg/ml concentration. No treatment-related toxicity or death was seen in any of the animals receiving dosages of 500 and 5000 mg/kg during the course of the 28-day study period, according to sub-acute oral toxicity tests. Additionally, no significant alterations (p > 0.05) were detected in hematological or biochemical parameters across the dosed groups. The administration of Charmagaz seed oil led to a modest elevation in high-density lipoprotein cholesterol, likely due to its polyunsaturated fatty acids content. Since the liver is a major organ involved in lipid metabolism hence, histopathological analysis was conducted to determine the effects of Charmagaz oil on hepatic tissues. The analysis revealed a positive correlation with biochemical results from liver function enzyme tests. Thus, this study provides evidence suggesting the safety of Charmagaz oil consumption at doses up to 5000 mg/kg.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2025 (prima pubblicazione 2025-07-11).
Identificativi: PMID 40644426 · PMCID PMC12250630 · DOI 10.1371/journal.pone.0327697.
Descrittori MeSH principali: Cucurbitaceae; Seeds; Plant Oils.
Pagina: https://europepmc.org/article/MED/40644426 — https://doi.org/10.1371/journal.pone.0327697. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T09:43:20.370Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.