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Quantile-specific heritability of plasma fibrinogen concentrations — Europe PMC PMID:34995330

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34995330
DOI: 10.1371/journal.pone.0262395
License (as archived): CC0-1.0
Archived: 2026-10-31T16:35:15.169Z
SHA-256 of the archived text: 44524571ab7f8404ea2f8de39c0c2438b4d22068e119d160bb702f7cbea984f2
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Quantile-specific heritability of plasma fibrinogen concentrations — Europe PMC PMID:34995330 — Europe PMC (en), https://europepmc.org/article/MED/34995330 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_640771ed366d (Metraipolis archive dc_640771ed366d, sha256 44524571ab7f8404ea2f8de39c0c2438b4d22068e119d160bb702f7cbea984f2)

BibTeX

@misc{dc640771ed366d,
  title = {Quantile-specific heritability of plasma fibrinogen concentrations — Europe PMC PMID:34995330},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34995330},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_640771ed366d; sha256 44524571ab7f8404ea2f8de39c0c2438b4d22068e119d160bb702f7cbea984f2},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34995330. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Fibrinogen is a moderately heritable blood protein showing different genetic effects by sex, race, smoking status, pollution exposure, and disease status. These interactions may be explained in part by "quantile-dependent expressivity", where the effect size of a genetic variant depends upon whether the phenotype (e.g. plasma fibrinogen concentration) is high or low relative to its distribution. Purpose: Determine whether fibrinogen heritability (h2) is quantile-specific, and whether quantile-specific h2 could account for fibrinogen gene-environment interactions. Methods: Plasma fibrinogen concentrations from 5689 offspring-parent pairs and 1932 sibships from the Framingham Heart Study were analyzed. Quantile-specific heritability from offspring-parent (βOP, h2 = 2βOP/(1+rspouse)) and full-sib regression slopes (βFS, h2 = {(1+8rspouseβFS)0.05-1}/(2rspouse)) were robustly estimated by quantile regression with nonparametric significance assigned from 1000 bootstrap samples. Results: Quantile-specific h2 (±SE) increased with increasing percentiles of the offspring's age- and sex-adjusted fibrinogen distribution when estimated from βOP (Ptrend = 5.5x10-6): 0.30±0.05 at the 10th, 0.37±0.04 at the 25th, 0.48±0.05 at the 50th, 0.61±0.06 at the 75th, and 0.65±0.08 at the 90th percentile, and when estimated from βFS (Ptrend = 0.008): 0.28±0.04 at the 10th, 0.31±0.04 at the 25th, 0.36±0.03 at the 50th, 0.41±0.05 at the 75th, and 0.50±0.06 at the 90th percentile. The larger genetic effect at higher average fibrinogen concentrations may contribute to fibrinogen's greater heritability in women than men and in Blacks than Whites, and greater increase from smoking and air pollution for the FGB -455G>A A-allele. It may also explain greater fibrinogen differences between: 1) FGB -455G>A genotypes during acute phase reactions than usual conditions, 2) GTSM1 and IL-6 -572C>G genotypes in smokers than nonsmokers, 3) FGB -148C>T genotypes in untreated than treated diabetics, and LPL PvuII genotypes in macroalbuminuric than normoalbuminuric patients. Conclusion: Fibrinogen heritability is quantile specific, which may explain or contribute to its gene-environment interactions. The analyses do not disprove the traditional gene-environment interpretations of these examples, rather quantile-dependent expressivity provides an alternative explanation that warrants consideration.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2022 (prima pubblicazione 2022-01-07).
Identificativi: PMID 34995330 · PMCID PMC8741049 · DOI 10.1371/journal.pone.0262395.
Pagina: https://europepmc.org/article/MED/34995330 — https://doi.org/10.1371/journal.pone.0262395. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-31T16:24:41.742Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.