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Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution — Europe PMC PMID:32876050

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32876050
DOI: 10.7554/elife.60067
License (as archived): CC0-1.0
Archived: 2026-11-07T15:38:11.021Z
SHA-256 of the archived text: 49d8a293f5cd195561ad07884825b26ad9c7dd829525c16c1d4d091f9536a572
Stable URL of this page: https://metraipolis.com/documento/dc_63f23fceeeff

How to cite

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution — Europe PMC PMID:32876050 — Europe PMC (en), https://europepmc.org/article/MED/32876050 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_63f23fceeeff (Metraipolis archive dc_63f23fceeeff, sha256 49d8a293f5cd195561ad07884825b26ad9c7dd829525c16c1d4d091f9536a572)

BibTeX

@misc{dc63f23fceeeff,
  title = {Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution — Europe PMC PMID:32876050},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32876050},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_63f23fceeeff; sha256 49d8a293f5cd195561ad07884825b26ad9c7dd829525c16c1d4d091f9536a572},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32876050. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Seasonal influenza virus A/H3N2 is a major cause of death globally. Vaccination remains the most effective preventative. Rapid mutation of hemagglutinin allows viruses to escape adaptive immunity. This antigenic drift necessitates regular vaccine updates. Effective vaccine strains need to represent H3N2 populations circulating one year after strain selection. Experts select strains based on experimental measurements of antigenic drift and predictions made by models from hemagglutinin sequences. We developed a novel influenza forecasting framework that integrates phenotypic measures of antigenic drift and functional constraint with previously published sequence-only fitness estimates. Forecasts informed by phenotypic measures of antigenic drift consistently outperformed previous sequence-only estimates, while sequence-only estimates of functional constraint surpassed more comprehensive experimentally-informed estimates. Importantly, the best models integrated estimates of both functional constraint and either antigenic drift phenotypes or recent population growth.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2020 (prima pubblicazione 2020-09-02).
Identificativi: PMID 32876050 · PMCID PMC7553778 · DOI 10.7554/elife.60067.
Parole chiave degli autori: Prediction; Evolution; Virus; Microbiology; Infectious disease; Influenza; Phenotypes; Evolutionary Biology; Antigenic Drift.
Descrittori MeSH principali: Genotype; Phenotype.
Pagina: https://europepmc.org/article/MED/32876050 — https://doi.org/10.7554/elife.60067. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-07T15:33:37.720Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.