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Diagnostic testing of chronic wasting disease in white-tailed deer (Odocoileus virginianus) by RT-QuIC using multiple tissues — Europe PMC PMID:36383520

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/36383520
DOI: 10.1371/journal.pone.0274531
License (as archived): CC0-1.0
Archived: 2026-10-15T16:00:43.539Z
SHA-256 of the archived text: 7d062b41da7fc3e020f0325e15ddb9949c1dc592d5592691652c6f3e24f9fab3
Stable URL of this page: https://metraipolis.com/documento/dc_62e5166751cd

How to cite

Diagnostic testing of chronic wasting disease in white-tailed deer (Odocoileus virginianus) by RT-QuIC using multiple tissues — Europe PMC PMID:36383520 — Europe PMC (en), https://europepmc.org/article/MED/36383520 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_62e5166751cd (Metraipolis archive dc_62e5166751cd, sha256 7d062b41da7fc3e020f0325e15ddb9949c1dc592d5592691652c6f3e24f9fab3)

BibTeX

@misc{dc62e5166751cd,
  title = {Diagnostic testing of chronic wasting disease in white-tailed deer (Odocoileus virginianus) by RT-QuIC using multiple tissues — Europe PMC PMID:36383520},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/36383520},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_62e5166751cd; sha256 7d062b41da7fc3e020f0325e15ddb9949c1dc592d5592691652c6f3e24f9fab3},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/36383520. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Chronic wasting disease (CWD) is a fatal prion disease affecting cervids (deer, elk, moose). Current methods to monitor individual disease state include highly invasive antemortem rectal biopsy or postmortem brain biopsy. Efficient, sensitive, and selective antemortem and postmortem testing of populations would increase knowledge of the dynamics of CWD epizootics as well as provide a means to track CWD progression into previously unaffected areas. Here, we analyzed the presence of CWD prions in skin samples from two easily accessed locations (ear and belly) from 30 deceased white-tailed deer (Odocoileus viginianus). The skin samples were enzymatically digested and analyzed by real-time quaking-induced conversion (RT-QuIC). The diagnostic sensitivity of the ear and belly skin samples were both 95%, and the diagnostic specificity of the ear and belly skin were both 100%. Additionally, the location of the skin biopsy on the ear does not affect specificity or sensitivity. These results demonstrate the efficacy of CWD diagnosis with skin biopsies using RT-QuIC. This method could be useful for large scale antemortem population testing.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2022 (prima pubblicazione 2022-11-16).
Identificativi: PMID 36383520 · PMCID PMC9668146 · DOI 10.1371/journal.pone.0274531.
Descrittori MeSH principali: Deer; Wasting Disease, Chronic; Prions.
Pagina: https://europepmc.org/article/MED/36383520 — https://doi.org/10.1371/journal.pone.0274531. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-15T15:24:45.055Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.