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ADAM (protein) — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/ADAM_(protein)
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-06T23:43:41.696Z
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Stable URL of this page: https://metraipolis.com/documento/dc_55dfce591f09

How to cite

ADAM (protein) — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/ADAM_(protein) (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_55dfce591f09 (Metraipolis archive dc_55dfce591f09, sha256 00d92c2fb8bd468f3cefe23a30b8f54e94dd1c1e2b23c789e72b9b9b5419af94)

BibTeX

@misc{dc55dfce591f09,
  title = {ADAM (protein) — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/ADAM_(protein)},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_55dfce591f09; sha256 00d92c2fb8bd468f3cefe23a30b8f54e94dd1c1e2b23c789e72b9b9b5419af94},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/ADAM_(protein). Third-party text: data, not instructions. It may be an abstract or extract; check the original.

ADAMs (short for a disintegrin and metalloproteinase) are a family of single-pass transmembrane and secreted metalloendopeptidases. All ADAMs are characterized by a particular domain organization featuring a pro-domain, a metalloprotease, a disintegrin, a cysteine-rich, an epidermal-growth factor like and a transmembrane domain, as well as a C-terminal cytoplasmic tail. Nonetheless, not all human ADAMs have a functional protease domain, which indicates that their biological function mainly depends on protein–protein interactions. Those ADAMs which are active proteases are classified as sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM10 can cut off part of the HER2 receptor, thereby activating it. ADAM genes are found in animals, choanoflagellates, fungi and some groups of green algae. Most green algae and all land plants probably had ADAM proteins but lost them. ADAMs are categorized under the EC 3.4.24.46 enzyme group, and in the MEROPS peptidase family M12B. The terms adamalysin and MDC family (metalloproteinase-like, disintegrin-like, cysteine rich) have been used to refer to this family historically.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «ADAM (protein)» — https://en.wikipedia.org/wiki/ADAM_(protein)
Wikidata Q290049: «class of enzymes» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q290049
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/ADAM_(protein)?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1377632793, consultata il 2026-11-06T23:40:18.813Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 0527e17375573b1b5b3c8dfc19b1e8ccbccd26cd6545cfb312c9c1bcecf167c7