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Air Pollution, Clustering of Particulate Matter Components, and Breast Cancer in the Sister Study: A U.S.-Wide Cohort — Europe PMC PMID:31596602

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31596602
DOI: 10.1289/ehp5131
License (as archived): CC0-1.0
Archived: 2026-11-10T09:35:22.819Z
SHA-256 of the archived text: 8088b4120bc623c5b263e94a811286698a3a477d58535ff480d49d1ccd3ad153
Stable URL of this page: https://metraipolis.com/documento/dc_552fddfcf2e4

How to cite

Air Pollution, Clustering of Particulate Matter Components, and Breast Cancer in the Sister Study: A U.S.-Wide Cohort — Europe PMC PMID:31596602 — Europe PMC (en), https://europepmc.org/article/MED/31596602 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_552fddfcf2e4 (Metraipolis archive dc_552fddfcf2e4, sha256 8088b4120bc623c5b263e94a811286698a3a477d58535ff480d49d1ccd3ad153)

BibTeX

@misc{dc552fddfcf2e4,
  title = {Air Pollution, Clustering of Particulate Matter Components, and Breast Cancer in the Sister Study: A U.S.-Wide Cohort — Europe PMC PMID:31596602},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31596602},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_552fddfcf2e4; sha256 8088b4120bc623c5b263e94a811286698a3a477d58535ff480d49d1ccd3ad153},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31596602. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Particulate matter (PM) is a complex mixture. Geographic variations in PM may explain the lack of consistent associations with breast cancer. Objective: We aimed to evaluate the relationship between air pollution, PM components, and breast cancer risk in a United States-wide prospective cohort. Methods: We estimated annual average ambient residential levels of particulate matter k -means were used to assign participants to clusters derived from PM2.5 component profiles to evaluate the impact of heterogeneity in the PM2.5 mixture. For PM2.5, we investigated effect measure modification by component cluster membership and by geographic region without regard to air pollution mixture. Results: During follow-up (mean=8.4 y), 2,225 invasive and 623 ductal carcinoma in situ (DCIS) cases were identified. PM2.5 and NO2 were associated with breast cancer overall [HR=1.05 (95% CI:0.99, 1.11) and 1.06 (95% CI:1.02, 1.11), respectively] and with DCIS but not with invasive cancer. Invasive breast cancer was associated with PM2.5 only in the Western United States [HR=1.14 (95% CI:1.02, 1.27)] and NO2 only in the Southern United States [HR=1.16 (95% CI:1.01, 1.33)]. PM2.5 was associated with a higher risk of invasive breast cancer among two of seven identified composition-based clusters. A higher risk was observed [HR=1.25 (95% CI: 0.97, 1.60)] in a California-based cluster characterized by low S and high Na and nitrate (NO3-) fractions and for another Western United States cluster [HR=1.60 (95% CI: 0.90, 2.85)], characterized by high fractions of Si, Ca, K, and Al. Conclusion: Air pollution measures were related to both invasive breast cancer and DCIS within certain geographic regions and PM component clusters. https://doi.org/10.1289/EHP5131.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2019 (prima pubblicazione 2019-10-09).
Identificativi: PMID 31596602 · PMCID PMC6867190 · DOI 10.1289/ehp5131.
Descrittori MeSH principali: Air Pollutants; Particulate Matter.
Pagina: https://europepmc.org/article/MED/31596602 — https://doi.org/10.1289/ehp5131. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-10T09:31:20.569Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.