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Cardiopulmonary, metabolic, and perceptual responses during exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Multi-site Clinical… — Europe PMC PMID:35290404

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/35290404
DOI: 10.1371/journal.pone.0265315
License (as archived): CC0-1.0
Archived: 2026-10-31T06:32:21.846Z
SHA-256 of the archived text: 0ee0b2bf3eaf9fc353d2f33dee266319518519918568a542dbcf5c70a6c97bd6
Stable URL of this page: https://metraipolis.com/documento/dc_4e66f528261b

How to cite

Cardiopulmonary, metabolic, and perceptual responses during exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Multi-site Clinical… — Europe PMC PMID:35290404 — Europe PMC (en), https://europepmc.org/article/MED/35290404 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_4e66f528261b (Metraipolis archive dc_4e66f528261b, sha256 0ee0b2bf3eaf9fc353d2f33dee266319518519918568a542dbcf5c70a6c97bd6)

BibTeX

@misc{dc4e66f528261b,
  title = {Cardiopulmonary, metabolic, and perceptual responses during exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Multi-site Clinical… — Europe PMC PMID:35290404},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/35290404},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_4e66f528261b; sha256 0ee0b2bf3eaf9fc353d2f33dee266319518519918568a542dbcf5c70a6c97bd6},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/35290404. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Cardiopulmonary exercise testing has demonstrated clinical utility in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, to what extent exercise responses are independent of, or confounded by, aerobic fitness remains unclear. Purpose: To characterize and compare exercise responses in ME/CFS and controls with and without matching for aerobic fitness. Methods: As part of the Multi-site Clinical Assessment of ME/CFS (MCAM) study, 403 participants (n = 214 ME/CFS; n = 189 controls), across six ME/CFS clinics, completed ramped cycle ergometry to volitional exhaustion. Metabolic, heart rate (HR), and ratings of perceived exertion (RPE) were measured. Ventilatory equivalent ([Formula: see text], [Formula: see text]), metrics of ventilatory efficiency, and chronotropic incompetence (CI) were calculated. Exercise variables were compared using Hedges' g effect size with 95% confidence intervals. Differences in cardiopulmonary and perceptual features during exercise were analyzed using linear mixed effects models with repeated measures for relative exercise intensity (20-100% peak [Formula: see text]). Subgroup analyses were conducted for 198 participants (99 ME/CFS; 99 controls) matched for age (±5 years) and peak [Formula: see text] (~1 ml/kg/min-1). Results: Ninety percent of tests (n = 194 ME/CFS, n = 169 controls) met standard criteria for peak effort. ME/CFS responses during exercise (20-100% peak [Formula: see text]) were significantly lower for ventilation, breathing frequency, HR, measures of efficiency, and CI and significantly higher for [Formula: see text], [Formula: see text] and RPE (p<0.05adjusted). For the fitness-matched subgroup, differences remained for breathing frequency, [Formula: see text], [Formula: see text], and RPE (p<0.05adjusted), and higher tidal volumes were identified for ME/CFS (p<0.05adjusted). Exercise responses at the gas exchange threshold, peak, and for measures of ventilatory efficiency (e.g., [Formula: see text]) were generally reflective of those seen throughout exercise (i.e., 20-100%). Conclusion: Compared to fitness-matched controls, cardiopulmonary responses to exercise in ME/CFS are characterized by inefficient exercise ventilation and augmented perception of effort. These data highlight the importance of distinguishing confounding fitness effects to identify responses that may be more specifically associated with ME/CFS.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2022 (prima pubblicazione 2022-03-15).
Identificativi: PMID 35290404 · PMCID PMC8923458 · DOI 10.1371/journal.pone.0265315.
Descrittori MeSH principali: Fatigue Syndrome, Chronic; Exercise.
Pagina: https://europepmc.org/article/MED/35290404 — https://doi.org/10.1371/journal.pone.0265315. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
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