Metraipolis › archive › dc_4af5d784eeee

Alpha-lytic endopeptidase — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Alpha-lytic_endopeptidase
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-08T17:08:50.112Z
SHA-256 of the archived text: 09c9268df6480851d5735ef41faa46e100f19383e573fd51cef7642a6e3624e9
Stable URL of this page: https://metraipolis.com/documento/dc_4af5d784eeee

How to cite

Alpha-lytic endopeptidase — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Alpha-lytic_endopeptidase (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_4af5d784eeee (Metraipolis archive dc_4af5d784eeee, sha256 09c9268df6480851d5735ef41faa46e100f19383e573fd51cef7642a6e3624e9)

BibTeX

@misc{dc4af5d784eeee,
  title = {Alpha-lytic endopeptidase — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Alpha-lytic_endopeptidase},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_4af5d784eeee; sha256 09c9268df6480851d5735ef41faa46e100f19383e573fd51cef7642a6e3624e9},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Alpha-lytic_endopeptidase. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Alpha-lytic endopeptidase or Alpha-lytic protease (EC 3.4.21.12, myxobacter alpha-lytic proteinase, alpha-lytic proteinase, alpha-lytic protease, Mycobacterium sorangium alpha-lytic proteinase, Myxobacter 495 alpha-lytic proteinase) is an enzyme isolated from the myxobacterium Lysobacter enzymogenes. This enzyme is a serine protease that catalyses the breakage of peptide bonds using a hydrolysis chemical reaction. Alpha-lytic protease was named based on the observed cleavage specificity for the α position of the tetrapeptide component in gram-positive bacterial cell walls (alanine). Alpha-lytic protease is also capable of digesting elastin and other proteins. This protease was recently applied to proteome digestion for production of peptides for mass spectrometry-based proteomics, where it was found to cleave preferentially after several small amino acids, including alanine, serine, threonine, valine, and to a lesser extent, methionine. This specificity is very different than the most commonly used protease for proteomics, trypsin, which cleaves only after arginine and lysine. Alpha-lytic protease was also recently reported to find utility as part of a method to map endogenous SUMO modification sites in the proteome.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «Alpha-lytic endopeptidase» — https://en.wikipedia.org/wiki/Alpha-lytic_endopeptidase
Wikidata Q12357575: «class of enzymes» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q12357575
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Alpha-lytic_endopeptidase?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1368834012, consultata il 2026-11-08T17:04:58.582Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 882b9636c6f8fd3623c4d783811321b8f9c471fce1c05d1af759dfa2deb1d46a