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Self-reported COVID-19 severity among persons with tuberculosis infection in western Kenya, 2021 — Europe PMC PMID:40305503

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40305503
DOI: 10.1371/journal.pgph.0004372
License (as archived): CC0-1.0
Archived: 2026-10-06T11:29:49.989Z
SHA-256 of the archived text: 0ea2e94d5c11dd66bc68a6e2bca0a8a6a925963ba429861862fdbf0e0cb01b15
Stable URL of this page: https://metraipolis.com/documento/dc_4530da78c398

How to cite

Self-reported COVID-19 severity among persons with tuberculosis infection in western Kenya, 2021 — Europe PMC PMID:40305503 — Europe PMC (en), https://europepmc.org/article/MED/40305503 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_4530da78c398 (Metraipolis archive dc_4530da78c398, sha256 0ea2e94d5c11dd66bc68a6e2bca0a8a6a925963ba429861862fdbf0e0cb01b15)

BibTeX

@misc{dc4530da78c398,
  title = {Self-reported COVID-19 severity among persons with tuberculosis infection in western Kenya, 2021 — Europe PMC PMID:40305503},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40305503},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_4530da78c398; sha256 0ea2e94d5c11dd66bc68a6e2bca0a8a6a925963ba429861862fdbf0e0cb01b15},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40305503. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Whilst a quarter of the world's population is estimated to be infected with Mycobacterium tuberculosis, it is unknown whether TB infection (TBI) increases the risk of severe COVID-19, which is relevant in TB-endemic settings, especially where HIV co-infection is also common. A convenience cohort of symptomatic and asymptomatic COVID-19 patients aged 8-80 years in western Kenya was followed daily for 14 days to assess disease progression using the validated inFLUenza-Patient-Reported-Outcome Plus signs and symptom tool. Nasal swabbing for SARS-CoV-2 was conducted to confirm the virus using polymerase chain reaction. QuantiFERON-TB Gold Plus was used to diagnose TBI. HIV status was based on self-reports. Between January 3, 2021, and January 20, 2022, 373 out of 387 participants had conclusive QuantiFERON results. At baseline, 5.9% (22/373) had self-reported severe COVID-19, 33.2% (124/373) had TBI, and 11.1% (38/341) reported being HIV-infected. Median follow-up of the cohort was 105 days (range 0-368). Self-reported severe COVID-19 was experienced by 10 of 124 (8.1%) participants compared with 12 of 249 (4.8%) without TBI (odds ratio [OR] 1.73, 95% CI 0.73-4.12, p = 0.21). HIV was not associated with self-reported severe COVID-19 (OR 3.13, 0.96-8.77, p = 0.039, adjusted OR 2.77, 95%CI 0.84-7.93, p = 0.070), but age ≥ 50 years was associated with self-reported severe COVID-19 (OR 3.73, 1.47-9.07, p = 0.004, adjusted OR 2.91, 95%CI 1.02-7.69, p = 0.035). One participant died of COVID-19 three days after diagnosis, and another participant developed active TB 128 days after his COVID-19 diagnosis and was successfully treated. Both were QuantiFERON positive. Self-reported severe COVID-19 was associated with older age and not TBI. Our finding that increased age was associated with self-reported severe COVID-19 is consistent with findings in multiple settings around the world.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLOS global public health, 2025 (prima pubblicazione 2025-04-30).
Identificativi: PMID 40305503 · PMCID PMC12043119 · DOI 10.1371/journal.pgph.0004372.
Pagina: https://europepmc.org/article/MED/40305503 — https://doi.org/10.1371/journal.pgph.0004372. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T09:52:30.038Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.