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Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological… — Europe PMC PMID:34310196

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34310196
DOI: 10.1289/ehp8421
License (as archived): CC0-1.0
Archived: 2026-11-03T12:06:50.786Z
SHA-256 of the archived text: f40bc3ab347b647c749424f7437ad40c7114cc11127fa7a22c556b1311f28293
Stable URL of this page: https://metraipolis.com/documento/dc_447e119683ef

How to cite

Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological… — Europe PMC PMID:34310196 — Europe PMC (en), https://europepmc.org/article/MED/34310196 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_447e119683ef (Metraipolis archive dc_447e119683ef, sha256 f40bc3ab347b647c749424f7437ad40c7114cc11127fa7a22c556b1311f28293)

BibTeX

@misc{dc447e119683ef,
  title = {Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological… — Europe PMC PMID:34310196},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34310196},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_447e119683ef; sha256 f40bc3ab347b647c749424f7437ad40c7114cc11127fa7a22c556b1311f28293},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34310196. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Growing epidemiological evidence suggests that organochlorine chemicals (OCCs), including 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), may play a role in the pathogenesis of endometriosis. Objectives: We aimed to systematically review the experimental evidence ( in vivo and in vitro ) on the associations between exposure to OCCs and endometriosis-related end points. Methods: A systematic review protocol was developed following the National Toxicology Program /Office of Health Assessment and Translation (NTP/OHAT) framework and managed within a web-based interface. In vivo studies designed to evaluate the impact of OCCs on the onset or progression of endometriosis and proliferation of induced endometriotic lesions were eligible. Eligible in vitro studies included single-cell and co-culture models to evaluate the proliferation, migration, and/or invasion of endometrial cells. We applied the search strings to PubMed, Web of Science, and Scopus®. A final search was performed on 24 June 2020. Assessment of risk of bias and the level of evidence and integration of preevaluated epidemiological evidence was conducted using NTP/OHAT framework Results: Out of 812 total studies, 39 met the predetermined eligibility criteria (15 in vivo , 23 in vitro , and 1 both). Most studies (n=27) tested TCDD and other dioxin-like chemicals. In vivo evidence supported TCDD's promotion of endometriosis onset and lesion growth. In vitro evidence supported TCDD's promotion of cell migration and invasion, but there was insufficient evidence for cell proliferation. In vitro evidence further supported the roles of the aryl hydrocarbon receptor and matrix metalloproteinases in mediating steroidogenic disruption and inflammatory responses. Estrogen interactions were found across studies and end points. Conclusion: Based on the integration of a high level of animal evidence with a moderate level of epidemiological evidence, we concluded that TCDD was a known hazard for endometriosis in humans and the conclusion is supported by mechanistic in vitro evidence. Nonetheless, there is need for further research to fill in our gaps in understanding of the relationship between OCCs and their mixtures and endometriosis, beyond the prototypical TCDD. https://doi.org/10.1289/EHP8421.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2021 (prima pubblicazione 2021-07-26).
Identificativi: PMID 34310196 · PMCID PMC8312885 · DOI 10.1289/ehp8421.
Descrittori MeSH principali: Endometriosis; Dioxins; Polychlorinated Dibenzodioxins.
Pagina: https://europepmc.org/article/MED/34310196 — https://doi.org/10.1289/ehp8421. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
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