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The seroepidemiology of dengue in a US military population based in Puerto Rico during the early phase of the Zika pandemic — Europe PMC PMID:35061659

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/35061659
DOI: 10.1371/journal.pntd.0009986
License (as archived): CC0-1.0
Archived: 2026-10-31T13:31:04.953Z
SHA-256 of the archived text: 2fb65704fab5d2453df828d54f41d9288ea5d57e36739a153c11d66281d77287
Stable URL of this page: https://metraipolis.com/documento/dc_43ca857048fd

How to cite

The seroepidemiology of dengue in a US military population based in Puerto Rico during the early phase of the Zika pandemic — Europe PMC PMID:35061659 — Europe PMC (en), https://europepmc.org/article/MED/35061659 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_43ca857048fd (Metraipolis archive dc_43ca857048fd, sha256 2fb65704fab5d2453df828d54f41d9288ea5d57e36739a153c11d66281d77287)

BibTeX

@misc{dc43ca857048fd,
  title = {The seroepidemiology of dengue in a US military population based in Puerto Rico during the early phase of the Zika pandemic — Europe PMC PMID:35061659},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/35061659},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_43ca857048fd; sha256 2fb65704fab5d2453df828d54f41d9288ea5d57e36739a153c11d66281d77287},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/35061659. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Understanding the burden and risk factors of dengue virus (DENV) infection in Puerto Rico is important for the prevention of dengue in local, traveler and military populations. Using sera from the Department of Defense Serum Repository, we estimated the prevalence and predictors of DENV seropositivity in those who had served in Puerto Rico, stratified by birth or prior residence ("birth/residence") in dengue-endemic versus non-endemic regions. We selected sera collected in early 2015 from 500 U.S. military members, a time-point also permitting detection of early cryptic Zika virus (ZIKV) circulation. 87.2% were born or resided in a DENV-endemic area before their military service in Puerto Rico. A high-throughput, flow-cytometry-based neutralization assay was employed to screen sera for ZIKV and DENV neutralizing antibodies, and confirmatory testing was done by plaque-reduction neutralization test (PRNT). We identified one Puerto Rico resident who seroconverted to ZIKV by June 2015, suggesting cryptic ZIKV circulation in Puerto Rico at least 4 months before the first reported cases. A further six PRNT-positive presumptive ZIKV infections which were resolved as DENV infections only by the use of paired sera. We noted 66.8% of the total study sample was DENV seropositive by early 2015. Logistic regression analysis indicated that birth/residence in a dengue non-endemic region (before military service in Puerto Rico) was associated with a lower odds of DENV exposure by January-June 2015 (aOR = 0.28, p = 0.001). Among those with birth/residence in a non-endemic country, we noted moderate evidence to support increase in odds of DENV exposure for each year of military service in Puerto Rico (aOR = 1.58, p = 0.06), but no association with age. In those with birth/residence in dengue-endemic regions (before military service in Puerto Rico), we noted that age (aOR = 1.04, p = 0.02), rather than duration of Puerto Rico service, was associated with dengue seropositivity, suggesting earlier lifetime DENV exposure. Our findings provide insights into the burden and predictors of DENV infection in local, traveler and military populations in Puerto Rico. Our study also highlights substantial PRNT ZIKV false-positivity when paired sera are not available, even during periods of very low ZIKV prevalence.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS neglected tropical diseases, 2022 (prima pubblicazione 2022-01-21).
Identificativi: PMID 35061659 · PMCID PMC8846501 · DOI 10.1371/journal.pntd.0009986.
Descrittori MeSH principali: Military Personnel.
Pagina: https://europepmc.org/article/MED/35061659 — https://doi.org/10.1371/journal.pntd.0009986. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-31T13:19:32.540Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.