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Development, refinement, and characterization of a nonhuman primate critical care environment — Europe PMC PMID:36930612

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/36930612
DOI: 10.1371/journal.pone.0281548
License (as archived): CC0-1.0
Archived: 2026-10-07T14:07:31.723Z
SHA-256 of the archived text: c06a3197bcd083940817f6e908a941e5701c8f6fdde44f0dc641a6ce72481781
Stable URL of this page: https://metraipolis.com/documento/dc_3efd201546ec

How to cite

Development, refinement, and characterization of a nonhuman primate critical care environment — Europe PMC PMID:36930612 — Europe PMC (en), https://europepmc.org/article/MED/36930612 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_3efd201546ec (Metraipolis archive dc_3efd201546ec, sha256 c06a3197bcd083940817f6e908a941e5701c8f6fdde44f0dc641a6ce72481781)

BibTeX

@misc{dc3efd201546ec,
  title = {Development, refinement, and characterization of a nonhuman primate critical care environment — Europe PMC PMID:36930612},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/36930612},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_3efd201546ec; sha256 c06a3197bcd083940817f6e908a941e5701c8f6fdde44f0dc641a6ce72481781},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/36930612. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Systemic inflammatory response remains a poorly understood cause of morbidity and mortality after traumatic injury. Recent nonhuman primate (NHP) trauma models have been used to characterize the systemic response to trauma, but none have incorporated a critical care phase without the use of general anesthesia. We describe the development of a prolonged critical care environment with sedation and ventilation support, and also report corresponding NHP biologic and inflammatory markers. Methods: Eight adult male rhesus macaques underwent ventilation with sedation for 48-96 hours in a critical care setting. Three of these NHPs underwent "sham" procedures as part of trauma control model development. Blood counts, chemistries, coagulation studies, and cytokines/chemokines were collected throughout the study, and histopathologic analysis was conducted at necropsy. Results: Eight NHPs were intentionally survived and extubated. Three NHPs were euthanized at 72-96 hours without extubation. Transaminitis occurred over the duration of ventilation, but renal function, acid-base status, and hematologic profile remained stable. Chemokine and cytokine analysis were notable for baseline fold-change for Il-6 and Il-1ra (9.7 and 42.7, respectively) that subsequently downtrended throughout the experiment unless clinical respiratory compromise was observed. Conclusions: A NHP critical care environment with ventilation support is feasible but requires robust resources. The inflammatory profile of NHPs is not profoundly altered by sedation and mechanical ventilation. NHPs are susceptible to the pulmonary effects of short-term ventilation and demonstrate a similar bioprofile response to ventilator-induced pulmonary pathology. This work has implications for further development of a prolonged care NHP model.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2023 (prima pubblicazione 2023-03-17).
Identificativi: PMID 36930612 · PMCID PMC10022766 · DOI 10.1371/journal.pone.0281548.
Descrittori MeSH principali: Respiration, Artificial; Critical Care; Veterinary Medicine.
Pagina: https://europepmc.org/article/MED/36930612 — https://doi.org/10.1371/journal.pone.0281548. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T14:02:28.661Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.