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Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis — Europe PMC PMID:34648530

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34648530
DOI: 10.1371/journal.pone.0258187
License (as archived): CC0-1.0
Archived: 2026-11-02T10:37:56.590Z
SHA-256 of the archived text: c3c51b4c666b7735e0b7a6e2b83d5ddd5a50b8af22ca673034133ffb24b23326
Stable URL of this page: https://metraipolis.com/documento/dc_3ce91bdcc227

How to cite

Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis — Europe PMC PMID:34648530 — Europe PMC (en), https://europepmc.org/article/MED/34648530 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_3ce91bdcc227 (Metraipolis archive dc_3ce91bdcc227, sha256 c3c51b4c666b7735e0b7a6e2b83d5ddd5a50b8af22ca673034133ffb24b23326)

BibTeX

@misc{dc3ce91bdcc227,
  title = {Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis — Europe PMC PMID:34648530},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34648530},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_3ce91bdcc227; sha256 c3c51b4c666b7735e0b7a6e2b83d5ddd5a50b8af22ca673034133ffb24b23326},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34648530. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Nasopharyngeal carcinoma (NPC) is a cancer of epithelial origin with a high incidence in certain populations. While NPC has a high remission rate with concomitant chemoradiation, recurrences are frequent, and the downstream morbidity of treatment is significant. Thus, it is imperative to find alternative therapies. Methods: We employed a Search Tag Analyze Resource (STARGEO) platform to conduct a meta-analysis using the National Center for Biotechnology's (NCBI) Gene Expression Omnibus (GEO) to define NPC pathogenesis. We identified 111 tumor samples and 43 healthy nasopharyngeal epithelium samples from NPC public patient data. We analyzed associated signatures in Ingenuity Pathway Analysis (IPA), restricting genes that showed statistical significance (p<0.05) and an absolute experimental log ratio greater than 0.15 between disease and control samples. Results: Our meta-analysis identified activation of lipopolysaccharide (LPS)-induced tissue injury in NPC tissue. Additionally, interleukin-1 (IL-1) and SB203580 were the top upstream regulators. Tumorigenesis-related genes such as homeobox A10 (HOXA10) and prostaglandin-endoperoxide synthase 2 (PTGS2 or COX-2) as well as those associated with extracellular matrix degradation, such as matrix metalloproteinases 1 and 3 (MMP-1, MMP-3) were also upregulated. Decreased expression of genes that encode proteins associated with maintaining healthy nasal respiratory epithelium structural integrity, including sentan-cilia apical structure protein (SNTN) and lactotransferrin (LTF) was documented. Importantly, we found that etanercept inhibits targets upregulated in NPC and LPS induction, such as MMP-1, PTGS2, and possibly MMP-3. Conclusions: Our analysis illustrates that nasal epithelial barrier dysregulation and maladaptive immune responses are key components of NPC pathogenesis along with LPS-induced tissue damage.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-10-14).
Identificativi: PMID 34648530 · PMCID PMC8516236 · DOI 10.1371/journal.pone.0258187.
Pagina: https://europepmc.org/article/MED/34648530 — https://doi.org/10.1371/journal.pone.0258187. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-02T10:29:46.744Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.