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Coronary endothelial dysfunction appears to be a manifestation of a systemic process: A report from the Women's Ischemia Syndrome Evaluation - Coronary… — Europe PMC PMID:34570768

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34570768
DOI: 10.1371/journal.pone.0257184
License (as archived): CC0-1.0
Archived: 2026-11-02T15:54:38.351Z
SHA-256 of the archived text: 93c4651ce89943b00ef276822d2c597c87a1fb650d78b43798576d5e0d346ac3
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Coronary endothelial dysfunction appears to be a manifestation of a systemic process: A report from the Women's Ischemia Syndrome Evaluation - Coronary… — Europe PMC PMID:34570768 — Europe PMC (en), https://europepmc.org/article/MED/34570768 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_3ce443dfd86f (Metraipolis archive dc_3ce443dfd86f, sha256 93c4651ce89943b00ef276822d2c597c87a1fb650d78b43798576d5e0d346ac3)

BibTeX

@misc{dc3ce443dfd86f,
  title = {Coronary endothelial dysfunction appears to be a manifestation of a systemic process: A report from the Women's Ischemia Syndrome Evaluation - Coronary… — Europe PMC PMID:34570768},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34570768},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_3ce443dfd86f; sha256 93c4651ce89943b00ef276822d2c597c87a1fb650d78b43798576d5e0d346ac3},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34570768. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Coronary microvascular dysfunction (CMD) is prevalent in symptomatic women with ischemia but no obstructive coronary artery disease (INOCA). Urine albumin-creatinine ratio (UACR) is a measure of renal microvascular endothelial dysfunction. Both are predictors of adverse cardiovascular events. It is unknown if CMD could be a manifestation of a systemic process. We evaluated the relationship between renal microvascular dysfunction and CMD as measured by invasive coronary function testing (CFT). Methods and results: We measured urine albumin and creatinine to provide UACR in 152 women enrolled in the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study (2008-2015) with suspected INOCA who underwent CFT. Invasive CFT measures of endothelial and non-endothelial dependent coronary microvascular function were obtained. Subjects were divided into those with detectable (≥20 mg/g) and undetectable urine albumin (<20 mg/g). The group mean age was 54 ± 11 years, with a moderate cardiac risk factor burden including low diabetes prevalence, and a mean UACR of 12 ± 55 mg/g (range 9.5-322.7 mg/g). Overall, coronary endothelial-dependent variables (change in coronary blood flow and coronary diameter in response to cold pressor testing) had significant inverse correlations with log UACR (r = -0.17, p = 0.05; r = -0.18, p = 0.03, respectively). Conclusions: Among women with INOCA and relatively low risk factor including diabetes burden, renal microvascular dysfunction, measured by UACR, is related to coronary endothelial-dependent CMD. These results suggest that coronary endothelial-dependent function may be a manifestation of a systemic process. Enhancing efferent arteriolar vasodilatation in both coronary endothelial-dependent function and renal microvascular dysfunction pose potential targets for investigation and treatment. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT00832702.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-09-27).
Identificativi: PMID 34570768 · PMCID PMC8476029 · DOI 10.1371/journal.pone.0257184.
Pagina: https://europepmc.org/article/MED/34570768 — https://doi.org/10.1371/journal.pone.0257184. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-02T15:46:47.727Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.