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Air Pollution and Progression of Atherosclerosis in Different Vessel Beds-Results from a Prospective Cohort Study in the Ruhr Area, Germany — Europe PMC PMID:33017176

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33017176
DOI: 10.1289/ehp7077
License (as archived): CC0-1.0
Archived: 2026-11-07T09:18:57.798Z
SHA-256 of the archived text: 84ecf1b9c3ead04820c58d7c8b4b9faacd77677d51f7fc36d408c4223c0a2c66
Stable URL of this page: https://metraipolis.com/documento/dc_397b74dee970

How to cite

Air Pollution and Progression of Atherosclerosis in Different Vessel Beds-Results from a Prospective Cohort Study in the Ruhr Area, Germany — Europe PMC PMID:33017176 — Europe PMC (en), https://europepmc.org/article/MED/33017176 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_397b74dee970 (Metraipolis archive dc_397b74dee970, sha256 84ecf1b9c3ead04820c58d7c8b4b9faacd77677d51f7fc36d408c4223c0a2c66)

BibTeX

@misc{dc397b74dee970,
  title = {Air Pollution and Progression of Atherosclerosis in Different Vessel Beds-Results from a Prospective Cohort Study in the Ruhr Area, Germany — Europe PMC PMID:33017176},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33017176},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_397b74dee970; sha256 84ecf1b9c3ead04820c58d7c8b4b9faacd77677d51f7fc36d408c4223c0a2c66},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33017176. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Objectives: Due to inconsistent epidemiological evidence on health effects of air pollution on progression of atherosclerosis, we investigated several air pollutants and their effects on progression of atherosclerosis, using carotid intima media thickness (cIMT), coronary calcification (CAC), and thoracic aortic calcification (TAC). Methods: We used baseline (2000-2003) and 5-y follow-up (2006-2008) data from the German Heinz Nixdorf Recall cohort study, including 4,814 middle-aged adults. Residence-based long-term air pollution exposure, including particulate matter (PM) with aerodynamic diameter ≤2.5μm (PM2.5), (PM10), and nitrogen dioxide (NO2) was assessed using chemistry transport and land use regression (LUR) models. cIMT was quantified as side-specific median IMT assessed from standardized ultrasound images. CAC and TAC were quantified by computed tomography using the Agatston score. Development (yes/no) and progression of atherosclerosis (change in cIMT and annual growth rate for CAC/TAC) were analyzed with logistic and linear regression models, adjusting for age, sex, lifestyle variables, socioeconomic status, and traffic noise. Results: While no clear associations were observed in the full study sample (mean age 59.1 (±7.6) y; 53% female), most air pollutants were marginally associated with progression of atherosclerosis in participants with no or low baseline atherosclerotic burden. Most consistently for CAC, e.g., a 1.5 μg/m3 higher exposure to PM2.5 (LUR) yielded an estimated odds ratio of 1.19 [95% confidence interval (CI): 1.03, 1.39] for progression of CAC and an increased annual growth rate of 2% (95% CI: 1%, 4%). Conclusion: Our study suggests that development and progression of subclinical atherosclerosis is associated with long-term air pollution in middle-aged participants with no or minor atherosclerotic burden at baseline, while overall no consistent associations are observed. https://doi.org/10.1289/EHP7077.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2020 (prima pubblicazione 2020-10-05).
Identificativi: PMID 33017176 · PMCID PMC7535085 · DOI 10.1289/ehp7077.
Pagina: https://europepmc.org/article/MED/33017176 — https://doi.org/10.1289/ehp7077. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-07T09:14:50.774Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.